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PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159JSNZLGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

Summary[edit | edit source]

  • pan ID?: SAUPAN002847000
  • symbol?:
  • synonym:
  • description?: Cro/CI family transcriptional regulator

      descriptions from strain specific annotations:

    • Cro/CI family transcriptional regulator
    • transcriptional regulator
    • Bacteriophage repressor
    • CI-like repressor, superantigen-encodingpathogenicity islands SaPI
  • strand?: -
  • coordinates?: 3297457..3297789
  • synteny block?: BlockID0020280
  • occurrence?: in 15% of 34 strains

immR : satellite pathogenicity island master transcriptional repressor ImmR [1]

The staphylococcal satellite pathogenicity island ImmA-ImmR-Str' regulatory switch is the functional equivalent of the cip-cI*-cro system from staphylococcal prophage. ImmR maintains the satellite pathogenicity island in the lysogeny phase until it is cleaved by activated ImmA protease. ImmR contains the canonical heptapeptide sequence TIAAHFD recognized by activated ImmA resulting in a processed 82-residue ImmR that is incapable of binding its operator. De-repression of ImmR occurs in three phases: initiation characterized by SIS binding to ImmR, sequestration characterized by ImmA binding to ImmR and proteolysis characterized by ImmA processing of ImmR. Although not experimentally-confirmed, the most likely ImmR operator site sequence is: THGTTCWYR-n2-YRWGAACDA

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    04-02981:
    08BA02176:
    11819-97:
    6850:
    71193:
    ECT-R 2:
    ED133:
    ED98:
    HO 5096 0412:
    JH1:
    JH9:
    JKD6008:
    JKD6159:
    JSNZ:
    LGA251:
    M013:
    M013TW_0811
    MRSA252:
    MSHR1132:
    MSSA476:
    Mu3:
    Mu50:
    MW2:
    RF122:
    ST398:
    T0131:
    SAT0131_00920 (lytM)
    TCH60:
    TW20:
    USA300_TCH1516:
    USA300HOU_0854
    VC40:

Genome Viewer[edit | edit source]

COL
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MRTNDEIITIIKTSMKEQNMSLSELARRVGVAKSAVSRYLNLTREFPLNRAEDFAKVLGI
    USA300_FPR3757  MRTNDEIITIIKTSMKEQNMSLSELARRVGVAKSAVSRYLNLTREFPLNRAEDFAKVLGI
                    ************************************************************

    COL             KTEYLLGFAEREESTKQDTIAAHLDGDFTEEELIEIRKYAELVRKAHRNQ
    USA300_FPR3757  KTEYLLGFAEREESTKQDTIAAHLDGDFTEEELIEIRKYAELVRKAHRNQ
                    **************************************************

  1. Jennifer M Auchtung, Catherine A Lee, Katherine L Garrison, Alan D Grossman
    Identification and characterization of the immunity repressor (ImmR) that controls the mobile genetic element ICEBs1 of Bacillus subtilis.
    Mol Microbiol: 2007, 64(6);1515-28
    [PubMed:17511812] [WorldCat.org] [DOI] (P p)
    Baundauna Bose, Jennifer M Auchtung, Catherine A Lee, Alan D Grossman
    A conserved anti-repressor controls horizontal gene transfer by proteolysis.
    Mol Microbiol: 2008, 70(3);570-82
    [PubMed:18761623] [WorldCat.org] [DOI] (I p)
    Tal Argov, Shai Ran Sapir, Anna Pasechnek, Gil Azulay, Olga Stadnyuk, Lev Rabinovich, Nadejda Sigal, Ilya Borovok, Anat A Herskovits
    Coordination of cohabiting phage elements supports bacteria-phage cooperation.
    Nat Commun: 2019, 10(1);5288
    [PubMed:31754112] [WorldCat.org] [DOI] (I e)