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PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159JSNZLGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40
⊟Summary[edit | edit source]
- pan ID?: SAUPAN004094000
- symbol?: —
- synonym:
- description?: membrane protein
- membrane protein
- Ribonuclease E domain-containing protein
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 4371050..4372897
- synteny block?: BlockID0031240
- occurrence?: in 26% of 34 strains
virB6 : ICE6013 membrane translocon extended channel protein VirB6 [1]
Some staphylococci have acquired a Type IV secretion system encoded on an integrative conjugative element (ICE6013), which encodes a minimal conjugative transfer function that may have adapted to double as a small molecule translocation system. Membrane translocon channel proteins assemble into a cell membrane-spanning pore with the VirB3-VirB4 hexamer-of-heterodimers ring on the cytoplasmic face and an extended C-terminal domain extending into the extracellular environment. The role of the extended C-terminal domain is unclear but may be involved in association with the VirB8 extracellular channel protein.
⊟Orthologs[edit | edit source]
04-02981:
—
08BA02176:
—
11819-97:
—
6850:
—
71193:
—
ECT-R 2:
—
ED133:
—
ED98:
—
HO 5096 0412:
SAEMRSA15_12360
JH1:
—
JH9:
—
JKD6008:
SAA6008_02634
JKD6159:
—
JSNZ:
—
LGA251:
—
M013:
—
MRSA252:
SAR1291
MSHR1132:
SAMSHR1132_15360
MSSA476:
—
Mu3:
—
Mu50:
—
MW2:
—
RF122:
—
ST398:
—
T0131:
SAT0131_02809 (thrC)
TCH60:
—
TW20:
SATW20_27160
USA300_TCH1516:
USA300HOU_0629
VC40:
—
⊟Genome Viewer[edit | edit source]
| COL | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKHKSVYLLCFLILPILLLTSVSAYAVSNPVGEPSHAVKPKIEKYDLSHYRSIYSEKGDW
USA300_FPR3757 MKHKSVYLLCFLILPILLLTSVSAYAVSNPVGEPSHAVKPKIEKYDLSHYRSIYSEKGDW
************************************************************
COL NPFGQEEISRQINNVSDFFFSMTKILAGVTDYAIENLFQLDVINDFADKIGDFVGDIYQK
USA300_FPR3757 NPFGQEEISRQINNVSDFFFSMTKILAGVTDYAIENLFQLDVINDFADKIGDFVGDIYQK
************************************************************
COL LLSNLAITLFIIVCFNAFIIFSVQGNAREALKRAFLIMCLIGFGVGILANAGNIIRGTNN
USA300_FPR3757 LLSNLALTLFIIVCFNAFIIFSVQGNAREALKRAFLIMCLIGFGVGILANAGNIIRGTNN
******:*****************************************************
COL IGKDLNNIIMNSTSSIDGNIDYIHENSGMNHIRNQLFDMTIYRTYLVMNYGTVDEKEIKA
USA300_FPR3757 IGKDLNNIIMNSTSSIDGNIDYIHENSGMNHIRNQLFDMTIYRTYLVMNYGTVDEKEIKA
************************************************************
COL KGKDRIDNILKQDFSKKGQDEIDKIVKNEVEKKDNKYMTQGYVFQKLAISVIGFIITVFM
USA300_FPR3757 KGKDRIDNILKLDYDKKSEKELDDIVKDEVEKKNNKYMTQGYVFQKLAISVIGFIITLFM
*********** *:.**.:.*:*.***:*****:***********************:**
COL SIVFLSISFAKLIFSTFALFLFLFLVFSWIVSFIPGFELSVFSAFAKTLGYIILSACMTF
USA300_FPR3757 SIVFLSISFAKLIFSTFALFLFLFLVFSWIVSFIPGFELSVFSAFAKTLGYIILSACMTF
************************************************************
COL LFVIVGLCIKLANSFIEPDSQNAYFLNSIFIIVILFVMYKKRAQIINFVSRGNISFSPSA
USA300_FPR3757 LFVIVGLCIKLANSFIEPDSQNAYFLNSIFIIVILFVMYKKRAQIINFVSRGNISFSPSA
************************************************************
COL IGAGVMNRTQERFNKIRHEQAQNKKAKRENQRDEPAPPLQNDNDLRRRQQDKPMPLFINK
USA300_FPR3757 IGAGVMNRTQERFNKIRHEQAQNKKAKRENQRDEPAPPLQNDNDLRRRQQDKPMPLFINK
************************************************************
COL DNQKNGNKRREQQESMNGNDVKSASVESNANDYSKQPQKASQQEHQVRETRQRKDIQRSP
USA300_FPR3757 DNQKNGNKRREQQESMNGNDVKSASVESNANNYSKQPQKASQQEHQVRETRQRKDIQRSP
*******************************:****************************
COL QVVNQPLNNENHSINRKEQKSVQTAYDTDVQKRQIQNATQNQQSRQSGNRNQPITRNSQS
USA300_FPR3757 QVVNQPLNNENHSINRKEQKSVQTAYDTDVQKRQIQNATQNQQSRQSGNRNQPITRNSQS
************************************************************
COL KDRLKEQKDINKHGK
USA300_FPR3757 KDRLKEQKDINKHGK
***************
- ↑ Zita Nagy, Mónika Szabó, Michael Chandler, Ferenc Olasz
Analysis of the N-terminal DNA binding domain of the IS30 transposase.
Mol Microbiol: 2004, 54(2);478-88
[PubMed:15469518] [WorldCat.org] [DOI] (P p)Davida S Smyth, D Ashley Robinson
Integrative and sequence characteristics of a novel genetic element, ICE6013, in Staphylococcus aureus.
J Bacteriol: 2009, 191(19);5964-75
[PubMed:19648240] [WorldCat.org] [DOI] (I p)Minny Bhatty, Jenny A Laverde Gomez, Peter J Christie
The expanding bacterial type IV secretion lexicon.
Res Microbiol: 2013, 164(6);620-39
[PubMed:23542405] [WorldCat.org] [DOI] (I p)Emily A Sansevere, Xiao Luo, Joo Youn Park, Sunghyun Yoon, Keun Seok Seo, D Ashley Robinson
Transposase-Mediated Excision, Conjugative Transfer, and Diversity of ICE6013 Elements in Staphylococcus aureus.
J Bacteriol: 2017, 199(8);
[PubMed:28138100] [WorldCat.org] [DOI] (I e)