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Summary[edit | edit source]

  • pan ID?: SAUPAN005052000
  • symbol?:
  • synonym:
  • description?: putative bacteriophage protein

      descriptions from strain specific annotations:

    • putative bacteriophage protein
    • phage protein
  • strand?: -
  • coordinates?: 5218493..5219882
  • synteny block?: BlockID0039290
  • occurrence?: in 56% of 34 strains

tacS (gpG) : serogroup F prophage tail assembly chaperone small subunit [1]

Staphylococcal prophages require tail assembly chaperone proteins (TACs) to coat the tape measure protein and prevent asynchronized and unstructured major tail tube protein binding. They will then nucleate major tail tube protein polymerization and be displaced by major tail tube protein subunits in orderly tail tube assembly. This small subunit is generated approximately 99% of the time - however, at a 1% frequency, a programmed translational frameshift at the A AAT TTT slippery coding sequence results in a longer "TacL" product represented by SAUPAN005050000. The balance of these two chaperone lengths allows TACs to properly coat the tape measure protein and prevent binding of both MtpS and MtpL subunits.

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    04-02981:
    SA2981_1917
    08BA02176:
    11819-97:
    6850:
    RSAU_000606
    71193:
    ST398NM01_2921
    ECT-R 2:
    ECTR2_1829
    ED133:
    ED98:
    HO 5096 0412:
    SAEMRSA15_18720
    JH1:
    SaurJH1_2048
    JH9:
    SaurJH9_2012
    JKD6008:
    SAA6008_02011
    JKD6159:
    JSNZ:
    LGA251:
    M013:
    MRSA252:
    SAR2052
    MSHR1132:
    SAMSHR1132_17970
    MSSA476:
    Mu3:
    SAHV_1942
    Mu50:
    SAV1956
    MW2:
    RF122:
    ST398:
    T0131:
    SAT0131_02090
    TCH60:
    HMPREF0772_11184
    TW20:
    SATW20_19490
    USA300_TCH1516:
    USA300HOU_1961
    VC40:

Genome Viewer[edit | edit source]

N315
Newman
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    N315            MAKLKRNIIQLVEDPKANEIKLQTYLTPHFISFEIVYEAMDLIDDIEDENSTMKPREIAD
    Newman          MAKLKRNIIQLVEDPKANEIKLQTYLTPHFISFEIVYEAMDLIDDIEDENSTMKPREIAD
    USA300_FPR3757  MAKLKRNIIQLVEDPKANEIKLQTYLTPHFISFEIVYEAMDLIDDIEDENSTMKPREIAD
                    ************************************************************

    N315            RLMDMVVKIYDNQFTVKDLKERMHAPDGMNALREQVIFITQGQQTEETRNFIQNMK
    Newman          RLMDMVVKIYDNQFTVKDLKERMHAPDGMNALREQVIFITQGQQTEETRNFIQNMK
    USA300_FPR3757  RLMDMVVKIYDNQFAVKDLKERMHAPDGMNALREQVVFITQGQQTEETRNFIQNMK
                    **************:*********************:*******************

  1. Jun Xu, Roger W Hendrix, Robert L Duda
    Conserved translational frameshift in dsDNA bacteriophage tail assembly genes.
    Mol Cell: 2004, 16(1);11-21
    [PubMed:15469818] [WorldCat.org] [DOI] (P p)
    Lisa G Pell, Nichole Cumby, Teresa E Clark, Ashleigh Tuite, Kevin P Battaile, Aled M Edwards, Nickolay Y Chirgadze, Alan R Davidson, Karen L Maxwell
    A conserved spiral structure for highly diverged phage tail assembly chaperones.
    J Mol Biol: 2013, 425(14);2436-49
    [PubMed:23542344] [WorldCat.org] [DOI] (I p)