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Summary[edit | edit source]

  • pan ID?: SAUPAN005527000
  • symbol?: rrlF
  • synonym:
  • description?: 23S ribosomal RNA
  • strand?: -
  • coordinates?: 5679108..5687152
  • synteny block?: BlockID0043060
  • occurrence?: in 97% of 34 strains

rrlF : 23S ribosomal RNA [1]

• A crystal structure is available : 6YEF

Staphylococcal 23S rRNA is modified by methylation at uridine(792) and at uridine(1966) by rlmCD, methylation and inversion at pseudouridine(1942) by rlmH and rluD, methylation at guanosine(2278) by rlmB, methylation at guanosine(2472) by rlmK, uridine reduction at dihydrouridine(2476), methylation at adenosine(2530) by rlmN, and methylation at guanosine(2601) by rlmQ.

Orthologs[edit | edit source]

    COL:
    SACOL_Sa23SF (rrlF)
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    04-02981:
    SA2981_rRNA15
    08BA02176:
    C248_2200
    11819-97:
    MS7_2187
    6850:
    RSAU_002008
    71193:
    ST398NM01_r062
    ECT-R 2:
    ECTR2_2025
    ED133:
    SAOV_2211c
    ED98:
    SAAV_2225a
    HO 5096 0412:
    SAEMRSA15_rRNA0018
    JH1:
    SaurJH1_R0080
    JH9:
    SaurJH9_R0080
    JKD6008:
    SAA6008_r15
    JKD6159:
    SAA6159_r15
    JSNZ:
    JSNZ_002132
    LGA251:
    SARLGA251_r13
    M013:
    M013TW_2130
    MRSA252:
    SARr015
    MSHR1132:
    SAMSHR1132_r14
    MSSA476:
    SASr018
    Mu3:
    SAHV_r0015
    Mu50:
    SAVrRNA15
    MW2:
    MWrRNA18
    RF122:
    SAB_r15
    ST398:
    T0131:
    SAT0131_r017
    TCH60:
    HMPREF0772_r10009
    TW20:
    SATW20_r150
    USA300_TCH1516:
    USA300HOU_r0015 (rrl5)
    VC40:
    SAVC_r12619

Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:

  1. Alexander Golubev, Bulat Fatkhullin, Iskander Khusainov, Lasse Jenner, Azat Gabdulkhakov, Shamil Validov, Gulnara Yusupova, Marat Yusupov, Konstantin Usachev
    Cryo-EM structure of the ribosome functional complex of the human pathogen Staphylococcus aureus at 3.2 Å resolution.
    FEBS Lett: 2020, 594(21);3551-3567
    [PubMed:32852796] [WorldCat.org] [DOI] (I p)
    Adrián González-López, Daniel S D Larsson, Ravi Kiran Koripella, Brett N Cain, Martin Garcia Chavez, Paul J Hergenrother, Suparna Sanyal, Maria Selmer
    Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane.
    Sci Rep: 2024, 14(1);14253
    [PubMed:38902339] [WorldCat.org] [DOI] (I e)
    Roberto Bahena-Ceron, Chloé Teixeira, Jose R Jaramillo Ponce, Philippe Wolff, Florence Couzon, Pauline François, Bruno P Klaholz, François Vandenesch, Pascale Romby, Karen Moreau, Stefano Marzi
    RlmQ: a newly discovered rRNA modification enzyme bridging RNA modification and virulence traits in Staphylococcus aureus.
    RNA: 2024, 30(3);200-212
    [PubMed:38164596] [WorldCat.org] [DOI] (I e)