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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005913000
- symbol?: sarZ
- synonym:
- description?: transcriptional regulator
- transcriptional regulator
- MarR family transcriptional regulator
- accessory protein Z
- MarR family regulatory protein
- transcriptional regulator, putative
- HTH-type transcriptional regulator SarZ
- HTH-type transcriptional regulator SarZ (Staphylococcal accessoryregulator Z)
- marR family protein
- staphylococcal accessory protein Z
- transcriptional regulator MarR family
- Transcriptional regulator SarZ (Staphylococcal accessory regulator Z)
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 5981759..5982232
- synteny block?: BlockID0046570
- occurrence?: in 100% of 34 strains
sarZ : modulator of SarA and Agr regulon transcriptional repressor SarZ [1]
• A crystal structure is available: 3HSE
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2323 (sarZ)
08BA02176:
C248_2433
11819-97:
MS7_2403 (sarZ)
6850:
RSAU_002224
71193:
ST398NM01_2439
ECT-R 2:
ECTR2_2245
ED133:
SAOV_2432
ED98:
SAAV_2451 (sarZ)
HO 5096 0412:
SAEMRSA15_22850
JH1:
SaurJH1_2457
JH9:
SaurJH9_2410
JKD6008:
SAA6008_02425
JKD6159:
SAA6159_02289
JSNZ:
JSNZ_002354
LGA251:
SARLGA251_21700 (sarZ)
M013:
M013TW_2346
MRSA252:
SAR2474
MSHR1132:
SAMSHR1132_22140
MSSA476:
SAS2276
Mu3:
SAHV_2370
Mu50:
SAV2386
MW2:
MW2306
RF122:
SAB2265
ST398:
SAPIG2439
T0131:
SAT0131_02576
TCH60:
HMPREF0772_10802 (sarZ)
TW20:
SATW20_25160 (sarZ)
USA300_TCH1516:
USA300HOU_2368
VC40:
SAVC_10795
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MYVENSYLSKQLCFLFYVSSKEIIKKYTNYLKEYDLTYTGYIVLMAIENDEKLNIKKLGE
N315 MYVENSYLSKQLCFLFYVSSKEIIKKYTNYLKEYDLTYTGYIVLMAIENDEKLNIKKLGE
NCTC8325 MYVENSYLSKQLCFLFYVSSKEIIKKYTNYLKEYDLTYTGYIVLMAIENDEKLNIKKLGE
Newman MYVENSYLSKQLCFLFYVSSKEIIKKYTNYLKEYDLTYTGYIVLMAIENDEKLNIKKLGE
USA300_FPR3757 MYVENSYLSKQLCFLFYVSSKEIIKKYTNYLKEYDLTYTGYIVLMAIENDEKLNIKKLGE
************************************************************
COL RVFLDSGTLTPLLKKLEKKDYVVRTREEKDERNLQISLTEQGKAIKSPLAEISVKVFNEF
N315 RVFLDSGTLTPLLKKLEKKDYVVRTREEKDERNLQISLTEQGKAIKSPLAEISVKVFNEF
NCTC8325 RVFLDSGTLTPLLKKLEKKDYVVRTREEKDERNLQISLTEQGKAIKSPLAEISVKVFNEF
Newman RVFLDSGTLTPLLKKLEKKDYVVRTREEKDERNLQISLTEQGKAIKSPLAEISVKVFNEF
USA300_FPR3757 RVFLDSGTLTPLLKKLEKKDYVVRTREEKDERNLQISLTEQGKAIKSPLAEISVKVFNEF
************************************************************
COL NISEREASDIINNLRNFVSKNFDYSDKK
N315 NISEREASDIINNLRNFVSKNFDYSDRK
NCTC8325 NISEREASDIINNLRNFVSKNFDYSDKK
Newman NISEREASDIINNLRNFVSKNFDYSDKK
USA300_FPR3757 NISEREASDIINNLRNFVSKNFDYSDKK
**************************:*
- ↑ Chikara Kaito, Daisuke Morishita, Yasuhiko Matsumoto, Kenji Kurokawa, Kazuhisa Sekimizu
Novel DNA binding protein SarZ contributes to virulence in Staphylococcus aureus.
Mol Microbiol: 2006, 62(6);1601-17
[PubMed:17087772] [WorldCat.org] [DOI] (P p)Sandeep Tamber, Ambrose L Cheung
SarZ promotes the expression of virulence factors and represses biofilm formation by modulating SarA and agr in Staphylococcus aureus.
Infect Immun: 2009, 77(1);419-28
[PubMed:18955469] [WorldCat.org] [DOI] (I p)Peng R Chen, Satoshi Nishida, Catherine B Poor, Alice Cheng, Taeok Bae, Lisa Kuechenmeister, Paul M Dunman, Dominique Missiakas, Chuan He
A new oxidative sensing and regulation pathway mediated by the MgrA homologue SarZ in Staphylococcus aureus.
Mol Microbiol: 2009, 71(1);198-211
[PubMed:19007410] [WorldCat.org] [DOI] (I p)Sophie Dyzenhaus, Mitchell J Sullivan, Bremy Alburquerque, Daiane Boff, Adriana van de Guchte, Marilyn Chung, Yi Fulmer, Richard Copin, Juliana K Ilmain, Anna O'Keefe, Deena R Altman, François-Xavier Stubbe, Magdalena Podkowik, Amy C Dupper, Bo Shopsin, Harm van Bakel, Victor J Torres
MRSA lineage USA300 isolated from bloodstream infections exhibit altered virulence regulation.
Cell Host Microbe: 2023, 31(2);228-242.e8
[PubMed:36681080] [WorldCat.org] [DOI] (I p)