PangenomeCOLN315NCTC8325NewmanUSA300_FPR3757JSNZ04-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 02-MAR-2017

⊟Summary

• organism: Staphylococcus aureus USA300_FPR3757
• locus tag: SAUSA300_RS02855 [old locus tag: SAUSA300_0534 ]
• pan locus tag^?: SAUPAN002321000
• symbol: SAUSA300_RS02855
• pan gene symbol^?: —
• synonym:
• product: N-acetyl-L,L-diaminopimelate deacetylase

⊟Additional information (user-provided)

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SAUSA300_RS02855 [old locus tag: SAUSA300_0534 ]
• symbol: SAUSA300_RS02855
• product: N-acetyl-L,L-diaminopimelate deacetylase
• replicon: chromosome
• strand: -
• coordinates: 598191..599366
• length: 1176
• essential: unknown other strains

⊟Accession numbers

• Location: NC_007793 (598191..599366) NCBI
• BioCyc: SAUSA300_RS02855 BioCyc
• MicrobesOnline: see SAUSA300_0534

⊟Phenotype

⊟Additional information (user-provided)

⊟DNA sequence

• 1
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  GTGTTAGATTGGTTCCAACTAGCAAATAATAAAGAAAATAAAACAATTCAACTCAGACGT
  TATTTACACCAATATCCTGAGTTATCTTTTGAAGAATTTCAAACACATGATTATATTGTT
  AACCAATTAAGCCAGTTATCTTGTGATATTGAAACTCCTATCGGCCGCAATGGTATCAAA
  GCCACATTTAAAGGCTTGGGCACAGGACCTACCATTGCATTAAGAGCTGACTTTGATGCG
  TTACCTGTCGAGGAATTAAACGATGTGCCTTATAAGTCTAAAAATCCAGGATGTATGCAT
  GCGTGTGGGCATGATGGTCATACAGCAATTTTACTTACTGTAGCAGAGATTTTAGATGAA
  CATAAACATTTATTAGAAGGTAATGTTGTATTAATATTCCAGTACGGTGAAGAAATCATG
  CCAGGTGGTTCTCAAGAAATGATAGATGCTGGATGTCTGGAAAATGTAGATAGAATTTAC
  GGTACACATTTATGGAGTGGTTATCCTACTGGAACTATTCATTCACGTGCGGGGGCAATC
  ATGGCCTCTCCAGATGAATTTAGCGTCACATTTAAAGGTCGTGGTGGTCATGGTGCCAAA
  CCTCATGAAACCATTGACCCAATAGTAATCATGGCAGAGTTCATTTTAAGTGCACAAAAA
  ATAATTTCACGTACGATCGATCCAGTTAAACAAGCTGTACTTTCATTTGGAATGATTCAA
  GCAGGCACCACAGATAGCGTTATTCCTGATCAAGCATTTTGTAAAGGTACAGTTAGAACT
  TTCGATTCAGATATACAGAATCATGTAATGGACAAAATGGATAAGCTTCTACAAGGTTTA
  GCAATAGCAAATGATATTAACTATGATTTGAATTATATTAAAGGGTATTTGCCTGTCCAT
  AATAACGAGAAAGCATATCAAGTTATTAAAGAAGCAACAAATGACTTACATGTACGCTTT
  AATGAATCAGATTTAATGATGATTGGAGAAGATTTTTCACATTATTTGAAAGTACGACCA
  GGTGCATTCTTTCTGACTGGTTGTGGTAATGAAAGTAAAGGTATTACAGCGCCACACCAT
  AATCCCAAATTTGATATTGATGAAAAATCATTAAAATACGCTGTAGCTGTATTTTTAAAA
  ATCATAGAATTAGAGCAAGTATTTAAAACAAATTAA
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⊟Protein

⊟General

• locus tag: SAUSA300_RS02855 [old locus tag: SAUSA300_0534 ]
• symbol: SAUSA300_RS02855
• description: N-acetyl-L,L-diaminopimelate deacetylase
• length: 391
• theoretical pI: 5.65496
• theoretical MW: 43657.4
• GRAVY: -0.23555

⊟Function

• TIGRFAM:
  Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides amidohydrolase (TIGR01891; HMM-score: 385.9)
  and 6 more
  Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides peptidase, ArgE/DapE family (TIGR01910; EC 3.4.-.-; HMM-score: 38)
  Metabolism Amino acid biosynthesis Glutamate family acetylornithine deacetylase (ArgE) (TIGR01892; EC 3.5.1.16; HMM-score: 30.7)
  amidase, hydantoinase/carbamoylase family (TIGR01879; EC 3.5.-.-; HMM-score: 26.5)
  Metabolism Amino acid biosynthesis Aspartate family succinyl-diaminopimelate desuccinylase (TIGR01246; EC 3.5.1.18; HMM-score: 24.2)
  Metabolism Amino acid biosynthesis Aspartate family succinyl-diaminopimelate desuccinylase (TIGR01900; EC 3.5.1.18; HMM-score: 21.7)
  Metabolism Central intermediary metabolism Nitrogen metabolism allantoate amidohydrolase (TIGR03176; EC 3.5.3.9; HMM-score: 17.3)
• TheSEED: see SAUSA300_0534
• PFAM:
  ZnExoPePases (CL0865) Peptidase_M20; Peptidase family M20/M25/M40 (PF01546; HMM-score: 147.1)
  and 2 more
  no clan defined M20_dimer; Peptidase dimerisation domain (PF07687; HMM-score: 41.7)
  ZnExoPePases (CL0865) Peptidase_M28; Peptidase family M28 (PF04389; HMM-score: 14.6)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9965
  • Cytoplasmic Membrane Score: 0.0008
  • Cell wall & surface Score: 0.0002
  • Extracellular Score: 0.0025
• LocateP:
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.008938
  • TAT(Tat/SPI): 0.000432
  • LIPO(Sec/SPII): 0.000589
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI: 446810659 NCBI
• RefSeq: WP_000887915 NCBI
• UniProt: see SAUSA300_0534

⊟Additional information (user-provided)

⊟Protein sequence

• MLDWFQLANNKENKTIQLRRYLHQYPELSFEEFQTHDYIVNQLSQLSCDIETPIGRNGIKATFKGLGTGPTIALRADFDALPVEELNDVPYKSKNPGCMHACGHDGHTAILLTVAEILDEHKHLLEGNVVLIFQYGEEIMPGGSQEMIDAGCLENVDRIYGTHLWSGYPTGTIHSRAGAIMASPDEFSVTFKGRGGHGAKPHETIDPIVIMAEFILSAQKIISRTIDPVKQAVLSFGMIQAGTTDSVIPDQAFCKGTVRTFDSDIQNHVMDKMDKLLQGLAIANDINYDLNYIKGYLPVHNNEKAYQVIKEATNDLHVRFNESDLMMIGEDFSHYLKVRPGAFFLTGCGNESKGITAPHHNPKFDIDEKSLKYAVAVFLKIIELEQVFKTN

⊟Experimental data

• experimentally validated: data available for COL, NCTC8325
• protein localization: data available for COL
• quantitative data / protein copy number per cell: data available for COL
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Additional information (user-provided)

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Additional information (user-provided)

⊟Other information (user-provided)

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications