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NCBI: 02-MAR-2017

⊟Summary[edit | edit source]

organism: Staphylococcus aureus USA300_FPR3757
locus tag: SAUSA300_RS14505 [old locus tag: SAUSA300_2609 ]
pan locus tag^?: SAUPAN006431000
symbol: SAUSA300_RS14505
pan gene symbol^?: hisB
synonym:
product: imidazoleglycerol-phosphate dehydratase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

type: CDS
locus tag: SAUSA300_RS14505 [old locus tag: SAUSA300_2609 ]
symbol: SAUSA300_RS14505
product: imidazoleglycerol-phosphate dehydratase
replicon: chromosome
strand: -
coordinates: 2836264..2836842
length: 579
essential: unknown other strains

⊟Accession numbers[edit | edit source]

Location: NC_007793 (2836264..2836842) NCBI
BioCyc: SAUSA300_RS14505 BioCyc
MicrobesOnline: see SAUSA300_2609

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

1
61
121
181
241
301
361
421
481
541
ATGATTTATCAAAAACAACGAAACACAGCTGAAACGCAACTAAATATTTCAATATCTGAT
GATCAGTCACCATCGCATATTAATACAGGTGTGGGCTTTTTAAATCATATGTTAACCTTG
TTTACATTTCATAGCGGTCTGTCATTAAACATTGAGGCACAAGGTGATATTGACGTAGAT
GATCACCACGTAACTGAAGATATCGGCATTGTCATTGGCCAATTGTTACTTGAAATGATT
AAAGATAAAAAGCATTTCGTTCGTTATGGAACGATGTACATTCCAATGGATGAAACATTA
GCACGTGTCGTTGTGGATATAAGTGGGCGCCCATACCTATCATTCAATGCATCATTAAGT
AAAGAAAAAGTTGGTACGTTTGATACGGAGTTAGTAGAAGAATTTTTTAGAGCGGTCGTA
ATCAATGCAAGATTAACAACGCATATTGATTTAATTCGTGGAGGTAATACACACCATGAA
ATTGAAGCTATATTCAAAGCGTTTTCCCGTGCATTAGGCATAGCGCTAACTGCAACTGAT
GATCAGCGTGTGCCGTCATCGAAAGGTGTGATTGAATGA
60
120
180
240
300
360
420
480
540
579

⊟Protein[edit | edit source]

2AE8
PDB

Protein Data Bank: 2AE8

⊟General[edit | edit source]

locus tag: SAUSA300_RS14505 [old locus tag: SAUSA300_2609 ]
symbol: SAUSA300_RS14505
description: imidazoleglycerol-phosphate dehydratase
length: 192
theoretical pI: 5.4988
theoretical MW: 21456.2
GRAVY: -0.0807292

⊟Function[edit | edit source]

reaction:
EC 4.2.1.19? ExPASy
Imidazoleglycerol-phosphate dehydratase D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H₂O
TIGRFAM:
TheSEED: see SAUSA300_2609
PFAM:
S5 (CL0329) IGPD; Imidazoleglycerol-phosphate dehydratase (PF00475; HMM-score: 200.3)

⊟Structure, modifications & cofactors[edit | edit source]

domains:
modifications:
cofactors:
effectors:

⊟Localization[edit | edit source]

PSORTb: Cytoplasmic
- Cytoplasmic Score: 9.97
- Cytoplasmic Membrane Score: 0
- Cellwall Score: 0.01
- Extracellular Score: 0.02
- Internal Helices: 0
LocateP:
SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.032907
- TAT(Tat/SPI): 0.008802
- LIPO(Sec/SPII): 0.000557
predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

GI: 446562920 NCBI
RefSeq: WP_000640266 NCBI
UniProt: see SAUSA300_2609

⊟Protein sequence[edit | edit source]

MIYQKQRNTAETQLNISISDDQSPSHINTGVGFLNHMLTLFTFHSGLSLNIEAQGDIDVDDHHVTEDIGIVIGQLLLEMIKDKKHFVRYGTMYIPMDETLARVVVDISGRPYLSFNASLSKEKVGTFDTELVEEFFRAVVINARLTTHIDLIRGGNTHHEIEAIFKAFSRALGIALTATDDQRVPSSKGVIE

⊟Experimental data[edit | edit source]

experimentally validated:
protein localization: data available for COL
quantitative data / protein copy number per cell:
interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

regulator: CodY, HisR* see SAUSA300_2609

⊟Transcription pattern[edit | edit source]

S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

Aureolib: no data available

⊟Protein stability[edit | edit source]

half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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