NCBI: 06-JUL-2013

⊟Summary

• organism: Staphylococcus aureus Newman
• locus tag: NWMN_1246 [new locus tag: NWMN_RS07035 ]
• pan locus tag^?: SAUPAN003707000
• symbol: katA
• pan gene symbol^?: katA
• synonym:
• product: catalase

⊟Gene

⊟General

• type: CDS
• locus tag: NWMN_1246 [new locus tag: NWMN_RS07035 ]
• symbol: katA
• product: catalase
• replicon: chromosome
• strand: +
• coordinates: 1369976..1371499
• length: 1524
• essential: unknown other strains

⊟Accession numbers

• Gene ID: 5330743 NCBI
• RefSeq: YP_001332280 NCBI
• MicrobesOnline: 3706798 MicrobesOnline

⊟Phenotype

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⊟DNA sequence

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  ATGACTATGTCACAACAAGACAAAAAGTTAACTGGTGTTTTTGGGCATCCAGTATCAGAC
  CGAGAAAATAGTATGACAGCAGGGCCTAGGGGACCTCTTTTAATGCAAGATATTTACTTT
  TTAGAGCAAATGTCTCAATTTGATAGAGAAGTAATACCAGAACGTCGAATGCATGCCAAA
  GGTTCTGGTGCATTTGGGACATTTACTGTAACTAAAGATATAACAAAATATACGAATGCT
  AAAATATTCTCTGAAATAGGTAAGCAAACCGAAATGTTTGCCCGTTTCTCTACTGTAGCA
  GGAGAACGTGGTGCTGCTGATGCGGAGCGTGACATTCGAGGATTTGCGTTAAAGTTCTAC
  ACTGAAGAAGGGAACTGGGATTTAGTAGGGAATAACACACCAGTATTCTTCTTTAGAGAT
  CCAAAGTTATTTGTTAGTTTAAATCGTGCGGTGAAACGAGATCCTAGAACAAATATGAGA
  GATGCACAAAATAACTGGGATTTCTGGACGGGTCTTCCAGAAGCATTGCACCAAGTAACG
  ATCTTAATGTCAGATAGAGGGATTCCTAAAGATTTACGTCATATGCATGGGTTCGGTTCT
  CACACATACTCTATGTATAATGATTCTGGTGAACGTGTTTGGGTTAAATTCCATTTTAGA
  ACGCAACAAGGTATTGAAAACTTAACTGATGAAGAAGCTGCTGAAATTATAGCTACAGAT
  CGTGATTCATCTCAACGCGATTTATTCGAAGCCATTGAAAAAGGTGATTATCCAAAATGG
  ACAATGTATATTCAAGTAATGACTGAGGAACAAGCTAAAAACCATAAAGATAATCCATTT
  GATTTAACAAAAGTATGGTATCACGATGAGTATCCTCTAATTGAAGTTGGAGAGTTTGAA
  TTAAATAGAAATCCAGATAATTACTTTATGGATGTTGAACAAGCTGCGTTTGCACCAACT
  AATATTATTCCAGGATTAGATTTTTCTCCAGACAAAATGCTGCAAGGGCGTTTATTCTCA
  TATGGCGATGCGCAAAGATATCGATTAGGAGTTAATCATTGGCAGATTCCTGTAAACCAA
  CCTAAAGGTGTTGGTATTGAAAATATTTGTCCTTTTAGTAGAGATGGTCAAATGCGCGTA
  GTTGACAATAACCAAGGTGGAGGAACACATTATTATCCAAATAACCATGGTAAATTTGAT
  TCTCAACCTGAATATAAAAAGCCACCATTCCCAACTGATGGATACGGCTATGAATATAAT
  CAACGTCAAGATGATGATAATTATTTTGAACAACCAGGTAAATTGTTTAGATTACAATCA
  GAGGACGCTAAAGAAAGAATTTTTACAAATACAGCAAATGCAATGGAAGGCGTAACGGAT
  GATGTTAAACGACGTCATATTCGTCATTGTTACAAAGCTGACCCAGAATATGGTAAAGGT
  GTTGCAAAAGCATTAGGTATTGATATAAATTCTATTGATCTTGAAACTGAAAATGATGAA
  ACATACGAAAACTTTGAAAAATAA
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  1524
  

⊟Protein

⊟General

• locus tag: NWMN_1246 [new locus tag: NWMN_RS07035 ]
• symbol: KatA
• description: catalase
• length: 507
• theoretical pI: 5.13252
• theoretical MW: 58611.8
• GRAVY: -0.840039

⊟Function

• reaction:
  EC 1.11.1.6?  ExPASy
  Catalase2 H₂O₂ = O₂ + 2 H₂O
• TIGRFAM:
• TheSEED:  
  Oxidative stress Catalase KatE (EC 1.11.1.6) 
  Protection from Reactive Oxygen Species Catalase KatE (EC 1.11.1.6) 
• PFAM:
  no clan definedCatalase; Catalase (PF00199; HMM-score: 606.9)
  Catalase-rel; Catalase-related immune-responsive (PF06628; HMM-score: 80.3)

⊟Structure, modifications & interactions

• domains:
• modifications:
• cofactors: heme
• effectors:
• protein partners:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 9.97
  • Cytoplasmic Membrane Score: 0
  • Cellwall Score: 0.01
  • Extracellular Score: 0.02
  • Internal Helices: 0
• LocateP: Intracellular
  • Prediction by SwissProt Classification: Cytoplasmic
  • Pathway Prediction: No pathway
  • Intracellular Possibility: 1
  • Signal Peptide Possibility: -1
  • N-terminally Anchored Score: -1
  • Predicted Cleavage Site: No CleavageSite
• SignalP: no predicted signal peptide
  • Ymax: 0.132
  • Ymax_pos: 11
  • Cmax: 0.106
  • Cmax_pos: 27
  • Smax: 0.252
  • Smax_pos: 1
  • Smean: 0.157
  • D: 0.142
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI: 151221458 NCBI
• RefSeq: YP_001332280 NCBI
• UniProt: A0A0H3K8E6 UniProt

⊟Protein sequence

• MTMSQQDKKLTGVFGHPVSDRENSMTAGPRGPLLMQDIYFLEQMSQFDREVIPERRMHAKGSGAFGTFTVTKDITKYTNAKIFSEIGKQTEMFARFSTVAGERGAADAERDIRGFALKFYTEEGNWDLVGNNTPVFFFRDPKLFVSLNRAVKRDPRTNMRDAQNNWDFWTGLPEALHQVTILMSDRGIPKDLRHMHGFGSHTYSMYNDSGERVWVKFHFRTQQGIENLTDEEAAEIIATDRDSSQRDLFEAIEKGDYPKWTMYIQVMTEEQAKNHKDNPFDLTKVWYHDEYPLIEVGEFELNRNPDNYFMDVEQAAFAPTNIIPGLDFSPDKMLQGRLFSYGDAQRYRLGVNHWQIPVNQPKGVGIENICPFSRDGQMRVVDNNQGGGTHYYPNNHGKFDSQPEYKKPPFPTDGYGYEYNQRQDDDNYFEQPGKLFRLQSEDAKERIFTNTANAMEGVTDDVKRRHIRHCYKADPEYGKGVAKALGIDINSIDLETENDETYENFEK

⊟Experimental data

• experimentally validated: no data available

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: katA no polycistronic organisation predicted

⊟Regulation

• sigma factor:
• regulators: NWMN_1753 (PerR*), CodY

  PerR*	(TF)	important in Oxidative stress response	RegPrecise
  CodY	(TF)	important in Amino acid metabolism	RegPrecise

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: data available for COL

⊟Protein stability

• half-life: no data available

⊟Other Information

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