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NCBI: 06-JUL-2013

Summary[edit source | edit]

  • organism: Staphylococcus aureus Newman
  • locus tag: NWMN_2410 [new locus tag: NWMN_RS13860 ]
  • pan locus tag?: SAUPAN006148000
  • symbol: NWMN_2410
  • pan gene symbol?:
  • synonym:
  • product: multidrug resistance transporter protein

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: NWMN_2410 [new locus tag: NWMN_RS13860 ]
  • symbol: NWMN_2410
  • product: multidrug resistance transporter protein
  • replicon: chromosome
  • strand: -
  • coordinates: 2653437..2654600
  • length: 1164
  • essential: unknown other strains

Accession numbers[edit source | edit]

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATGATTAATAGTAATATCAGATTATATATTCTAGGATTTTTAGCATTTTTCGCATCATTG
    ATTCAAAACATATACACGCCTATTATTCCGAGACTATATGACGATTTTCAAGTACCACTA
    TTTTGGATAAATGCGACAGTTGGCGGTTTTATATTTATCGTTGCAGTTATGCAAATTGTA
    CTTGGTAGAAGTATAGATTCTCGTGATTCGAAAAAAGTACTTTTAACGGGATTGGGAATA
    GTAATCATATCTAGCTTTATTTGTGCAGTGACACATAACTTTATATTATTTGCTATATCA
    AGGTTATTTCAAGCAATTGGTTGCGGAATTATTCCTCTCGTGACTTTAACTTTATTAGCC
    AAACTAAGTACAGATAATGGTAGAGCTCAAGCTATGGCGAACTATCAAATATTTTTATCA
    TGTGCACCAGCTTTGGCACCAATCTTAGGGAGTACTTTAGGTGCAAGATGGGATTATATT
    GGTATTTTTAGTTTTTTGCTCGTTATATCTATCGTATTATTTTTGATTATCTTTTTTATT
    GATATTCCAAATGTTGAAAAAGGGATTGTAAAATTAACTGAAAAAATTGAAGAAAAATAT
    TTGACCGATAAAGTGTTTATTACTTTAGTGACATTGGGATTTTTAATATTTTTTACGTAC
    TTTTCAATATTAGTTTATTTACCAACATTATTAAATAATACCTATGATATAGGCGTTGGA
    ATATCAGGAGTTTTGTTTTTACCTATTACTGTTAGTGTTATATTAGGAAGTTTATTTTAT
    AAGCGATTTTCAAAAAAATATAATGAAATAATGATACTTCGTGTTACTATAACTGGATTT
    GCTATATTTACGTTATTGTTTGGATGGTTAAACGAATCAAATGTAATTATATTATCAGTA
    ATTATATTTATATTAGGTACTTGTGTTGGTATTGTGCCAGCTTTGCTGTCTACTATAATT
    TCTAAAAGGTTTGAACATATAAAAGGGAAAGTGCTAGGTGTATTTAATTTTGTGAGATAT
    ATTGGAATGACTGTCGGTGCATTATTAATTGGTATCATTTCTCAGCCGTTGGTAGCCTTT
    TACTTCACAACTATAACTATCATGTTAATAGTAATATTTCTTTATATAAAGATAGTTGAC
    TTTCAGCTAAAGTATGCCAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1164

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: NWMN_2410 [new locus tag: NWMN_RS13860 ]
  • symbol: NWMN_2410
  • description: multidrug resistance transporter protein
  • length: 387
  • theoretical pI: 9.77147
  • theoretical MW: 43229.9
  • GRAVY: 1.11705

Function[edit source | edit]

  • reaction:
  • TIGRFAM:
    drug resistance transporter, Bcr/CflA subfamily (TIGR00710; HMM-score: 101.2)
    multidrug resistance protein (TIGR00880; HMM-score: 70.1)
    Cellular processesCellular processesToxin production and resistancedrug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family (TIGR00711; HMM-score: 55.6)
    MetabolismTransport and binding proteinsOtherdrug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family (TIGR00711; HMM-score: 55.6)
    MetabolismTransport and binding proteinsCarbohydrates, organic alcohols, and acidsMFS transporter, aromatic acid:H+ symporter (AAHS) family (TIGR00895; HMM-score: 28.7)
  • TheSEED:  
    Major facilitator family transporter 
  • PFAM:
    MFS (CL0015) MFS_1; Major Facilitator Superfamily (PF07690; HMM-score: 147.8)
    MFS_3; Transmembrane secretion effector (PF05977; HMM-score: 20.3)
    MFS_2; MFS/sugar transport protein (PF13347; HMM-score: 7)
    no clan definedDUF4220; Domain of unknown function (DUF4220) (PF13968; HMM-score: 5.7)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 12
  • LocateP: Multi-transmembrane
    • Prediction by SwissProt Classification: Membrane
    • Pathway Prediction: Sec-(SPI)
    • Intracellular Possibility: 0.17
    • Signal Peptide Possibility: -1
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • Ymax: 0.147
    • Ymax_pos: 11
    • Cmax: 0.119
    • Cmax_pos: 34
    • Smax: 0.265
    • Smax_pos: 6
    • Smean: 0.214
    • D: 0.173
  • predicted transmembrane helices (TMHMM): 12

Accession numbers[edit source | edit]

Protein sequence[edit source | edit]

  • MINSNIRLYILGFLAFFASLIQNIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSKKVLLTGLGIVIISSFICAVTHNFILFAISRLFQAIGCGIIPLVTLTLLAKLSTDNGRAQAMANYQIFLSCAPALAPILGSTLGARWDYIGIFSFLLVISIVLFLIIFFIDIPNVEKGIVKLTEKIEEKYLTDKVFITLVTLGFLIFFTYFSILVYLPTLLNNTYDIGVGISGVLFLPITVSVILGSLFYKRFSKKYNEIMILRVTITGFAIFTLLFGWLNESNVIILSVIIFILGTCVGIVPALLSTIISKRFEHIKGKVLGVFNFVRYIGMTVGALLIGIISQPLVAFYFTTITIMLIVIFLYIKIVDFQLKYAK

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]