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NCBI: 02-MAR-2017

Summary[edit source | edit]

  • organism: Staphylococcus aureus Newman
  • locus tag: NWMN_RS06680 [old locus tag: NWMN_1185 ]
  • pan locus tag?: SAUPAN003577000
  • symbol: NWMN_RS06680
  • pan gene symbol?: ftsK
  • synonym:
  • product: DNA translocase FtsK

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: NWMN_RS06680 [old locus tag: NWMN_1185 ]
  • symbol: NWMN_RS06680
  • product: DNA translocase FtsK
  • replicon: chromosome
  • strand: +
  • coordinates: 1306434..1308677
  • length: 2244
  • essential: unknown

Accession numbers[edit source | edit]

  • Location: NC_009641 (1306434..1308677) NCBI
  • MicrobesOnline:

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
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    481
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    901
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    1021
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    1141
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    1801
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    1921
    1981
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    2221
    ATGGTGTTGGGTGTTTTCCAATTAGGAATAATAGGTCGTCTAATTGACAGCTTCTTTAAT
    TATTTATTTGGGTACAGTAGATATTTAACATATATTTTAGTACTCTTAGCAACTGGTTTT
    ATTACATACTCTAAACGTATTCCTAAAACTAGACGAACGGCTGGTTCGATTGTATTGCAA
    ATTGCATTGCTATTTGTATCACAGTTAGTTTTTCATTTTAATAGTGGTATCAAAGCTGAA
    AGAGAACCTGTACTTTCTTATGTGTATCAGTCATACCAACATAGTCATTTCCCAAATTTT
    GGTGGCGGTGTATTAGGCTTTTATTTATTAGAGTTAAGCGTACCTTTAATTTCATTATTT
    GGTGTATGTATTATTACTATTTTATTATTATGCTCAAGTGTTATTTTATTAACAAACCAT
    CAACATCGTGAAGTTGCAAAAGTTGCACTGGAAAATATAAAAGCTTGGTTTGGTTCATTT
    AATGAAAAAATGTCGGAAAGAAACCAAGAAAAACAATTGAAGCGTGAAGAAAAAGCAAGA
    CTTAAAGAAGAACAAAAGGCACGTCAAAATGAACAGCCACAAATAAAAGATGTGAGTGAT
    TTTACGGAAGTGCCTCAAGAAAGAGATATTCCAATTTATGGGCATACTGAAAATGAAAGT
    AAAAGCCAGAGTCAACCAAGTCGAAAAAAACGAGTGTTTGATGCAGAGAATAGTTCGAAT
    AACATCGTAAATCATCATCAAGCAGATCAGCAAGAACAATTAACAGAACAAACTCATAAC
    AGTGTTGAAAGTGAAAACACTATTGAAGAAGCTGGTGAAGTTACGAATGTATCGTATGTT
    GTTCCACCGTTAACTTTACTTAATCAACCTGCAAAACAAAAAGCAACATCTAAAGCTGAA
    GTGCAACGTAAAGGACAAGTACTAGAGAATACATTAAAAGATTTTGGGGTAAATGCAAAA
    GTGACACAAATTAAAATTGGTCCTGCAGTAACTCAATATGAAATTCAACCAGCTCAAGGG
    GTTAAAGTGAGTAAAATTGTAAACTTGCATAATGATATTGCATTAGCTTTAGCAGCAAAA
    GATGTTAGAATCGAAGCGCCAATACCTGGTCGTTCTGCAGTAGGTATTGAAGTGCCAAAT
    GAGAAAATTTCATTAGTTTCACTAAAAGAAGTTTTAGATGAAAAATTCCCGTCTAATAAT
    AAACTAGAAGTTGGATTAGGAAGAGATATATCAGGTGATCCAATTACTGTTCCACTAAAT
    GAAATGCCACACTTATTGGTGGCAGGATCGACGGGTAGTGGTAAATCTGTTTGTATAAAT
    GGTATTATTACAAGTATTTTATTAAATGCTAAGCCGCATGAAGTTAAACTTATGTTAATC
    GATCCGAAAATGGTTGAACTAAATGTTTATAACGGAATTCCACACTTATTAATTCCGGTT
    GTTACAAATCCTCATAAAGCTGCTCAAGCTTTAGAAAAAATTGTAGCTGAGATGGAAAGA
    CGTTATGATTTATTCCAACATTCATCAACTAGAAACATTAAAGGTTATAACGAATTAATC
    CGTAAGCAAAATCAAGAATTAGATGAGAAGCAACCAGAATTACCTTATATCGTTGTTATT
    GTAGATGAGCTTGCAGATTTAATGATGGTAGCTGGTAAAGAAGTTGAAAATGCGATTCAA
    CGTATTACACAAATGGCACGTGCAGCAGGTATACATTTAATTGTAGCGACACAAAGACCT
    TCTGTGGATGTAATTACAGGTATCATTAAAAATAATATTCCATCTAGAATAGCTTTTGCT
    GTGAGTTCTCAAACAGATTCAAGAACTATTATTGGTACTGGCGGCGCAGAAAAGTTACTT
    GGTAAAGGTGACATGTTATACGTTGGAAATGGTGACTCATCACAAACACGTATTCAAGGG
    GCGTTTTTAAGTGACCAAGAGGTGCAAGATGTTGTAAATTATGTAGTAGAACAACAACAG
    GCAAATTATGTAAAAGAAATGGAACCAGATGCACCAGTGGATAAATCGGAAATGAAAAGT
    GAAGATGCTTTATATGATGAAGCGTATTTGTTTGTTGTTGAACAACAAAAGGCAAGTACA
    TCATTGTTACAACGCCAATTTAGAATTGGTTATAATAGAGCATCTAGGTTGATGGATGAT
    TTAGAACGCAATCAGGTAATCGGTCCACAAAAAGGAAGCAAGCCTAGACAAGTTTTAATA
    GATCTTAATAATGACGAGGTGTAA
    60
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    2160
    2220
    2244

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: NWMN_RS06680 [old locus tag: NWMN_1185 ]
  • symbol: NWMN_RS06680
  • description: DNA translocase FtsK
  • length: 747
  • theoretical pI: 6.62784
  • theoretical MW: 83404.8
  • GRAVY: -0.264391

Function[edit source | edit]

  • reaction:
  • TIGRFAM:
    Genetic information processingProtein fateProtein and peptide secretion and traffickingtype VII secretion protein EssC (TIGR03928; HMM-score: 124.1)
    Genetic information processingProtein fateProtein and peptide secretion and traffickingtype VII secretion protein EccCa (TIGR03924; HMM-score: 103)
    Genetic information processingProtein fateProtein and peptide secretion and traffickingtype VII secretion protein EccCb (TIGR03925; HMM-score: 65.2)
    Genetic information processingMobile and extrachromosomal element functionsOtherconjugative coupling factor TraD, SXT/TOL subfamily (TIGR03743; HMM-score: 15)
    type IV conjugative transfer system coupling protein TraD (TIGR02759; HMM-score: 12.4)
    MetabolismTransport and binding proteinsCations and iron carrying compoundscation transporter family protein (TIGR00860; HMM-score: 11.3)
  • TheSEED:
  • PFAM:
    P-loop_NTPase (CL0023) FtsK_SpoIIIE; FtsK/SpoIIIE family (PF01580; HMM-score: 205.7)
    HTH (CL0123) Ftsk_gamma; Ftsk gamma domain (PF09397; HMM-score: 100.8)
    P-loop_NTPase (CL0023) AAA_10; AAA-like domain (PF12846; HMM-score: 26.6)
    no clan definedFtsK_4TM; 4TM region of DNA translocase FtsK/SpoIIIE (PF13491; HMM-score: 21.9)
    P-loop_NTPase (CL0023) AAA_19; AAA domain (PF13245; HMM-score: 20.8)
    DUF87; Domain of unknown function DUF87 (PF01935; HMM-score: 20.5)
    AAA_22; AAA domain (PF13401; HMM-score: 16.9)
    T2SSE; Type II/IV secretion system protein (PF00437; HMM-score: 15.6)
    TrwB_AAD_bind; Type IV secretion-system coupling protein DNA-binding domain (PF10412; HMM-score: 14.9)
    ClpP_crotonase (CL0127) Peptidase_S49_N; Peptidase family S49 N-terminal (PF08496; HMM-score: 14.8)
    no clan definedNeur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region (PF02932; HMM-score: 14.5)
    P-loop_NTPase (CL0023) AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 14.2)
    AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 13.6)
    no clan definedCodanin-1_C; Codanin-1 C-terminus (PF15296; HMM-score: 11)
    Peptidase_AD (CL0130) Presenilin; Presenilin (PF01080; HMM-score: 7)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 3
  • LocateP:
  • SignalP: no predicted signal peptide
    • Ymax: 0.11
    • Ymax_pos: 68
    • Cmax: 0.172
    • Cmax_pos: 47
    • Smax: 0.165
    • Smax_pos: 55
    • Smean: 0.062
    • D: 0.091
  • predicted transmembrane helices (TMHMM): 4

Accession numbers[edit source | edit]

  • GI:
  • RefSeq: WP_001806691 NCBI
  • UniProt:

Protein sequence[edit source | edit]

  • MVLGVFQLGIIGRLIDSFFNYLFGYSRYLTYILVLLATGFITYSKRIPKTRRTAGSIVLQIALLFVSQLVFHFNSGIKAEREPVLSYVYQSYQHSHFPNFGGGVLGFYLLELSVPLISLFGVCIITILLLCSSVILLTNHQHREVAKVALENIKAWFGSFNEKMSERNQEKQLKREEKARLKEEQKARQNEQPQIKDVSDFTEVPQERDIPIYGHTENESKSQSQPSRKKRVFDAENSSNNIVNHHQADQQEQLTEQTHNSVESENTIEEAGEVTNVSYVVPPLTLLNQPAKQKATSKAEVQRKGQVLENTLKDFGVNAKVTQIKIGPAVTQYEIQPAQGVKVSKIVNLHNDIALALAAKDVRIEAPIPGRSAVGIEVPNEKISLVSLKEVLDEKFPSNNKLEVGLGRDISGDPITVPLNEMPHLLVAGSTGSGKSVCINGIITSILLNAKPHEVKLMLIDPKMVELNVYNGIPHLLIPVVTNPHKAAQALEKIVAEMERRYDLFQHSSTRNIKGYNELIRKQNQELDEKQPELPYIVVIVDELADLMMVAGKEVENAIQRITQMARAAGIHLIVATQRPSVDVITGIIKNNIPSRIAFAVSSQTDSRTIIGTGGAEKLLGKGDMLYVGNGDSSQTRIQGAFLSDQEVQDVVNYVVEQQQANYVKEMEPDAPVDKSEMKSEDALYDEAYLFVVEQQKASTSLLQRQFRIGYNRASRLMDDLERNQVIGPQKGSKPRQVLIDLNNDEV

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

  • NWMN_RS06680 no polycistronic organisation predicted

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]