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NCBI: 02-MAR-2017

Summary[edit | edit source]

  • organism: Staphylococcus aureus Newman
  • locus tag: NWMN_RS12005 [old locus tag: NWMN_2072 ]
  • pan locus tag?: SAUPAN005560000
  • symbol: NWMN_RS12005
  • pan gene symbol?:
  • synonym:
  • product: uridylyltransferase

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: NWMN_RS12005 [old locus tag: NWMN_2072 ]
  • symbol: NWMN_RS12005
  • product: uridylyltransferase
  • replicon: chromosome
  • strand: -
  • coordinates: 2308316..2309503
  • length: 1188
  • essential: unknown other strains

Accession numbers[edit | edit source]

  • Location: NC_009641 (2308316..2309503) NCBI
  • BioCyc:
  • MicrobesOnline: see NWMN_2072

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATGCTAGATAAAAATCAATTAGCTAAATATAAACAAGATCATTTGTGTGAATATGAAAAA
    ATAATGAGTAACAATGAAAAAGAAGCACTTGAAGAGAAGGTAGCGTCATTAGATTTAGAT
    TTTATTGCCAAATTATATAACGATTTATACATCAATAAGAAAACAATAGATGATGTATCT
    GCAGTTTCTGAAGTGAAATATGATATTAAATCACAAATGAGTGATGATGAGATTAAGCGT
    TTAGAGGAACAAGGACTTCAAGCTATTAAAGAAGGACAATTTGCAGTACTTTTGATGGCA
    GGTGGTCAAGGAACAAGACTTGGTTACAAGGGCCCTAAAGGTTCGTTTGAAATTGAAGGT
    GTAAGTTTATTTGAACTTCAAGCTAACCAATTAAAAACATTGAATCATCAATCTGGACAT
    ACGATTCAATGGTATATTATGACAAGTGATATCAATCATGAAGAAACTTTAGCTTATTTC
    GAAGCACATAGTTATTTTGGATATGATCAAGAAGCAATCCATTTCTTTAAACAAGATAAT
    ATTGTGGCGCTTAGTGAAGAAGGGAAGTTAATTTTAAATCAACAGGGTCGTATTATGGAA
    ACGCCGAATGGTAATGGTGGCGTGTTTAAATCTTTAGACAAGGCAGGATACTTAGAAGAA
    ATGTCTAATAATGGCGTTAAGTATATTTTCTTGAATAATATCGACAATGTTTTAGTAAGA
    GTGTTGGATCCACTATTTGCAGGATTTACGGTAGAACATGATTACGATATTACTTCTAAA
    ACGATTCAACCAAAACCAGGAGAAAGTGTTGGACGTTTAGTTAATGTCGATTGTAAAGAT
    ACAGTACTGGAGTATTCAGAATTAGATCCAGAAGTTGCAAATCAATTTAACAATGCTAAT
    ATCGGTATTCATGCATTTAAACTTGGTTTTATTTTAAACGCTGTAAATCGTGAGTTACCT
    TATCATTTAGCTATTAAGAATTTGAAGCAATTAGATGAGAACTTTGGTGTTATTGAACAA
    CCAACTTTAAAATTCGAATTGTTCTATTTTGACATATTTACTTATGGAACTAGTTTTGTC
    ACGTTACAAGTTCCTAGAGAAGAAGAATTTTCACCTCTTAAAAATAAAGAAGGTAAAGAT
    AGTGTTGCAACTGCAACAGAAGATTTACGTAGAATGGGTTTAATTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1188

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: NWMN_RS12005 [old locus tag: NWMN_2072 ]
  • symbol: NWMN_RS12005
  • description: uridylyltransferase
  • length: 395
  • theoretical pI: 4.60106
  • theoretical MW: 44893.4
  • GRAVY: -0.391899

Function[edit | edit source]

  • TIGRFAM:
    Hypothetical proteins Conserved TIGR00454 family protein (TIGR00454; HMM-score: 17)
    and 2 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Molybdopterin molybdenum cofactor guanylyltransferase (TIGR02665; EC 2.7.7.77; HMM-score: 13)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (TIGR00453; EC 2.7.7.60; HMM-score: 11.2)
  • TheSEED: data available for COL, N315, NCTC8325, USA300_FPR3757
  • PFAM:
    GT-A (CL0110) UDPGP; UTP--glucose-1-phosphate uridylyltransferase (PF01704; HMM-score: 141.1)
    and 1 more
    NTP_transf_3; MobA-like NTP transferase domain (PF12804; HMM-score: 17.9)

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001485
    • TAT(Tat/SPI): 0.000152
    • LIPO(Sec/SPII): 0.000474
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit | edit source]

Protein sequence[edit | edit source]

  • MLDKNQLAKYKQDHLCEYEKIMSNNEKEALEEKVASLDLDFIAKLYNDLYINKKTIDDVSAVSEVKYDIKSQMSDDEIKRLEEQGLQAIKEGQFAVLLMAGGQGTRLGYKGPKGSFEIEGVSLFELQANQLKTLNHQSGHTIQWYIMTSDINHEETLAYFEAHSYFGYDQEAIHFFKQDNIVALSEEGKLILNQQGRIMETPNGNGGVFKSLDKAGYLEEMSNNGVKYIFLNNIDNVLVRVLDPLFAGFTVEHDYDITSKTIQPKPGESVGRLVNVDCKDTVLEYSELDPEVANQFNNANIGIHAFKLGFILNAVNRELPYHLAIKNLKQLDENFGVIEQPTLKFELFYFDIFTYGTSFVTLQVPREEEFSPLKNKEGKDSVATATEDLRRMGLI

Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell: data available for COL
  • interaction partners:
    NWMN_RS08905isocitrate dehydrogenase (NADP(+))  [1] (data from MRSA252)
    NWMN_RS11910hypothetical protein  [1] (data from MRSA252)
    NWMN_RS11915ABC transporter permease  [1] (data from MRSA252)

Expression & Regulation[edit | edit source]

Operon[edit | edit source]

Regulation[edit | edit source]

Transcription pattern[edit | edit source]

Protein synthesis (provided by Aureolib)[edit | edit source]

Protein stability[edit | edit source]

  • half-life: no data available

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

Literature[edit | edit source]

References[edit | edit source]

  1. 1.0 1.1 1.2 Artem Cherkasov, Michael Hsing, Roya Zoraghi, Leonard J Foster, Raymond H See, Nikolay Stoynov, Jihong Jiang, Sukhbir Kaur, Tian Lian, Linda Jackson, Huansheng Gong, Rick Swayze, Emily Amandoron, Farhad Hormozdiari, Phuong Dao, Cenk Sahinalp, Osvaldo Santos-Filho, Peter Axerio-Cilies, Kendall Byler, William R McMaster, Robert C Brunham, B Brett Finlay, Neil E Reiner
    Mapping the protein interaction network in methicillin-resistant Staphylococcus aureus.
    J Proteome Res: 2011, 10(3);1139-50
    [PubMed:21166474] [WorldCat.org] [DOI] (I p)

Relevant publications[edit | edit source]