NCBI: 02-MAR-2017

⊟Summary

• organism: Staphylococcus aureus USA300_FPR3757
• locus tag: SAUSA300_RS05110 [old locus tag: SAUSA300_0951 ]
• pan locus tag^?: SAUPAN003251000
• symbol: SAUSA300_RS05110
• pan gene symbol^?: sspA
• synonym:
• product: serine protease

⊟Gene

⊟General

• type: CDS
• locus tag: SAUSA300_RS05110 [old locus tag: SAUSA300_0951 ]
• symbol: SAUSA300_RS05110
• product: serine protease
• replicon: chromosome
• strand: -
• coordinates: 1039542..1040552
• length: 1011
• essential: unknown

⊟Accession numbers

• Location: NC_007793 (1039542..1040552) NCBI
• MicrobesOnline:

⊟Phenotype

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⊟DNA sequence

• 1
  61
  121
  181
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  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  
  ATGAAAGGTAAATTTTTAAAAGTTAGTTCTTTATTCGTTGCAACTTTGACAACAGCGACA
  CTTGTGAGTTCTCCAGCAGCAAACGCGTTATCTTCAAAGGCTATGGACAATCATCCACAA
  CAAACGCAGTCAAGCAAACAGCAAACACCTAAGATTCAAAAAGGCGGTAACCTTAAACCA
  TTAGAACAACGTGAACACGCAAATGTTATATTACCAAATAACGATCGTCACCAAATCACA
  GATACAACGAATGGTCATTATGCACCCGTAACTTATATTCAAGTTGAAGCACCTACTGGT
  ACATTTATTGCTTCCGGTGTAGTTGTAGGTAAAGATACTCTTTTAACAAATAAACACGTC
  GTAGATGCTACGCACGGTGATCCTCATGCTTTAAAAGCATTCCCTTCTGCAATTAACCAA
  GACAATTATCCAAATGGTGGTTTCACTGCTGAACAAATCACTAAATATTCAGGCGAAGGT
  GATTTAGCAATAGTTAAATTCTCCCCTAATGAGCAAAACAAACATATTGGTGAAGTAGTT
  AAACCAGCAACAATGAGTAATAATGCTGAAACACAAGTTAACCAAAATATTACTGTAACA
  GGATATCCTGGTGATAAACCTGTAGCAACAATGTGGGAAAGTAAAGGAAAAATCACTTAC
  CTCAAAGGCGAAGCTATGCAATATGATTTAAGTACAACTGGTGGTAATTCAGGTTCACCT
  GTATTTAATGAAAAAAATGAAGTGATCGGAATTCATTGGGGCGGTGTACCAAATGAATTT
  AATGGTGCGGTATTTATTAATGAAAATGTACGCAACTTCTTAAAACAAAATATTGAAGAT
  ATCCATTTTGCCAACGATGACCAACCTAATAACCCAGATAATCCTGATAACCCTAACAAT
  CCTGATAACCCTAACAACCCAGATGAACCAAATAACCCTGACAACCCTAACAACCCTGAT
  AATCCAGACAATGGCGATAACAATAATTCAGACAATCCAGATGCAGCTTAA
  60
  120
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  420
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  1011
  

⊟Protein

⊟General

• locus tag: SAUSA300_RS05110 [old locus tag: SAUSA300_0951 ]
• symbol: SAUSA300_RS05110
• description: serine protease
• length: 336
• theoretical pI: 4.80889
• theoretical MW: 36325.4
• GRAVY: -0.839881

⊟Function

• reaction:
  EC 3.4.21.19?  ExPASy
  Glutamyl endopeptidasePreferential cleavage: Glu-|-Xaa, Asp-|-Xaa
• TIGRFAM:
  Genetic information processingProtein fateDegradation of proteins, peptides, and glycopeptidespeptidase Do (TIGR02037; EC 3.4.21.-; HMM-score: 18.1)
  Genetic information processingProtein fateProtein folding and stabilizationpeptidase Do (TIGR02037; EC 3.4.21.-; HMM-score: 18.1)
  Genetic information processingProtein fateDegradation of proteins, peptides, and glycopeptidesperiplasmic serine peptidase DegS (TIGR02038; EC 3.4.21.-; HMM-score: 13.3)
  Signal transductionRegulatory functionsProtein interactionsperiplasmic serine peptidase DegS (TIGR02038; EC 3.4.21.-; HMM-score: 13.3)
• TheSEED:
• PFAM:
  Peptidase_PA (CL0124) Trypsin_2; Trypsin-like peptidase domain (PF13365; HMM-score: 75.1)
  Trypsin; Trypsin (PF00089; HMM-score: 50.2)
  Peptidase_S46; Peptidase S46 (PF10459; HMM-score: 26.9)
  Peptidase_S7; Peptidase S7, Flavivirus NS3 serine protease (PF00949; HMM-score: 22.2)
  Peptidase_C3; 3C cysteine protease (picornain 3C) (PF00548; HMM-score: 18.4)
  Peptidase_S32; Equine arteritis virus serine endopeptidase S32 (PF05579; HMM-score: 17.2)
  Peptidase_S39; Peptidase S39 (PF02122; HMM-score: 16.1)
  Peptidase_CA (CL0125) Phytochelatin; Phytochelatin synthase (PF05023; HMM-score: 11.7)

⊟Structure, modifications & interactions

• domains:
• modifications:
• cofactors:
• effectors:
• protein partners:

⊟Localization

• PSORTb: Extracellular
  • Cytoplasmic Score: 0
  • Cytoplasmic Membrane Score: 0
  • Cellwall Score: 0
  • Extracellular Score: 10
  • Internal Helices: 0
• LocateP:
• SignalP: Signal peptide length 30 aa
  • Ymax: 0.552
  • Ymax_pos: 30
  • Cmax: 0.329
  • Cmax_pos: 30
  • Smax: 0.982
  • Smax_pos: 13
  • Smean: 0.944
  • D: 0.705
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI: 446599202 NCBI
• RefSeq: WP_000676548 NCBI
• UniProt:

⊟Protein sequence

• MKGKFLKVSSLFVATLTTATLVSSPAANALSSKAMDNHPQQTQSSKQQTPKIQKGGNLKPLEQREHANVILPNNDRHQITDTTNGHYAPVTYIQVEAPTGTFIASGVVVGKDTLLTNKHVVDATHGDPHALKAFPSAINQDNYPNGGFTAEQITKYSGEGDLAIVKFSPNEQNKHIGEVVKPATMSNNAETQVNQNITVTGYPGDKPVATMWESKGKITYLKGEAMQYDLSTTGGNSGSPVFNEKNEVIGIHWGGVPNEFNGAVFINENVRNFLKQNIEDIHFANDDQPNNPDNPDNPNNPDNPNNPDEPNNPDNPNNPDNPDNGDNNNSDNPDAA

⊟Experimental data

• experimentally validated: no data available

⊟Expression & Regulation

⊟Operon

• SAUSA300_RS05110 no polycistronic organisation predicted

⊟Regulation

• sigma factor:
• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser: no data available

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Other Information

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