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FunGene: 08-OCT-2024

Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_001639
  • pan locus tag?: SAUPAN004255000
  • symbol: mreC
  • pan gene symbol?: mreC
  • synonym:
  • product: rod shape-determining protein MreC

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_001639
  • symbol: mreC
  • product: rod shape-determining protein MreC
  • replicon: chromosome
  • strand: -
  • coordinates: 1674620..1675462
  • length: 843
  • essential: unknown other strains

Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    GTGCTTAAGTTTTTTAAAAATAACAAATTAATTGTTGTTTTATGTGCAATTATCGTTTTT
    ATTGCATTAATTGGGCTGTCCATACGTTCACAATCTCAATCACCTCCTGAACAATATATA
    GGTGATTCTGTGTCTTTTGGACAACGAGTTGTGAGTTATCCAGTTAATTTTGTTGCTGGT
    ACGATTGGGGACTTTTTTAAAAAAGGAGATTCTAAAGAATCTAAAAATAAGATTAGCCAG
    TTAGAATCTAAGAACCAACAATTAGAAGCGGAAAATGAAAAATTAAAAAAAGAGCTTGAT
    TTAAAAGATATTTCAAAATTTGATCCTATTTCTACTACGGTTTTAGCAAGAAATCCGGAT
    CAGTGGATGAATACAATTGTAATTGATAAGGGATCTAAATCAGGTATAACTTCAAATATG
    GCTGTGATGACATCACAAGGTTTTGTTGGAAGAGTTACTAAAGTTAATAAATTTTCTTCA
    CAAGTTGATTTAATCTCAACTAATACACGTGCGGGTAAATTATCTGTAAATATACAACAC
    GGTTCTAAAAATATATTTGGTTTAATTGATCGTTATGATGAAAAGAACTCAGAACTTGTA
    ATTAGTGACATTAATAATAGAGATAATATCTCAAAAGGTGATAAAGTCGTTACAAGTGGA
    TTAGCTGATCAACTACCAAGTAATTTATATATAGGAGAAGTGACTAAGGTTCAAAATGAT
    CAATACGGCTTAGCTAAAGAAGTTAGGGTTAAGACTGGTGCAGACTTAACAGATTTGAGT
    CATGTTTATGTTGCAAAAAGAGATCCTAAAACAATTCCTGATGATGAAGGCAGGGATAAA
    TAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    843

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: JSNZ_001639
  • symbol: MreC
  • description: rod shape-determining protein MreC
  • length: 280
  • theoretical pI: 9.59859
  • theoretical MW: 30980
  • GRAVY: -0.3975

Function[edit | edit source]

  • TIGRFAM:
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan rod shape-determining protein MreC (TIGR00219; HMM-score: 146.9)
    and 4 more
    Genetic information processing Mobile and extrachromosomal element functions Plasmid functions integrating conjugative element protein, PFL_4705 family (TIGR03752; HMM-score: 18.1)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking preprotein translocase, YajC subunit (TIGR00739; HMM-score: 15)
    integrating conjugative element protein, PFL_4669 family (TIGR03761; HMM-score: 12.1)
    Cellular processes Cellular processes Cell division cell division protein FtsL (TIGR02209; HMM-score: 4.9)
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    Peptidase_PA (CL0124) MreC; Rod shape-determining protein MreC, barrel core (PF04085; HMM-score: 136.7)
    and 10 more
    no clan defined YajC; Preprotein translocase subunit (PF02699; HMM-score: 23.7)
    TSC22; TSC-22/dip/bun family (PF01166; HMM-score: 17.2)
    FtsL (CL0225) DivIC; Septum formation initiator (PF04977; HMM-score: 15.4)
    no clan defined YabA; Initiation control protein YabA (PF06156; HMM-score: 15.4)
    bZIP (CL0018) bZIP_2; Basic region leucine zipper (PF07716; HMM-score: 15.2)
    bZIP_1; bZIP transcription factor (PF00170; HMM-score: 15)
    no clan defined Ariadne; Ariadne domain (PF19422; HMM-score: 14.6)
    HTH (CL0123) DUF6262; Family of unknown function (DUF6262) (PF19776; HMM-score: 14.6)
    TACC (CL0679) Fungal_TACC; Fungal Transforming acidic coiled-coil (TACC) proteins (PF12709; HMM-score: 14.5)
    no clan defined Shugoshin_N; Shugoshin N-terminal coiled-coil region (PF07558; HMM-score: 9.1)

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 3.33
    • Cellwall Score: 3.33
    • Extracellular Score: 3.33
    • Internal Helix: 1
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0008
    • Cytoplasmic Membrane Score: 0.9768
    • Cell wall & surface Score: 0.0005
    • Extracellular Score: 0.0219
  • LocateP:
  • SignalP: Signal peptide SP(Sec/SPI) length 32 aa
    • SP(Sec/SPI): 0.795076
    • TAT(Tat/SPI): 0.001816
    • LIPO(Sec/SPII): 0.137729
    • Cleavage Site: CS pos: 32-33. SQS-QS. Pr: 0.5493
  • predicted transmembrane helices (TMHMM): 1

Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

Protein sequence[edit | edit source]

  • MLKFFKNNKLIVVLCAIIVFIALIGLSIRSQSQSPPEQYIGDSVSFGQRVVSYPVNFVAGTIGDFFKKGDSKESKNKISQLESKNQQLEAENEKLKKELDLKDISKFDPISTTVLARNPDQWMNTIVIDKGSKSGITSNMAVMTSQGFVGRVTKVNKFSSQVDLISTNTRAGKLSVNIQHGSKNIFGLIDRYDEKNSELVISDINNRDNISKGDKVVTSGLADQLPSNLYIGEVTKVQNDQYGLAKEVRVKTGADLTDLSHVYVAKRDPKTIPDDEGRDK

Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell:
  • interaction partners:

Expression & Regulation[edit | edit source]

Operon[edit | edit source]

Regulation[edit | edit source]

  • regulator:

Transcription pattern[edit | edit source]

Protein synthesis (provided by Aureolib)[edit | edit source]

Protein stability[edit | edit source]

  • half-life: no data available

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

Literature[edit | edit source]

References[edit | edit source]

  1. Blanca Taboada, Karel Estrada, Ricardo Ciria, Enrique Merino
    Operon-mapper: a web server for precise operon identification in bacterial and archaeal genomes.
    Bioinformatics: 2018, 34(23);4118-4120
    [PubMed:29931111] [WorldCat.org] [DOI] (I p)

Relevant publications[edit | edit source]