PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 26-AUG-2013

⊟Summary

• organism: Staphylococcus aureus N315
• locus tag: SA1195 [new locus tag: SA_RS06795 ]
• pan locus tag^?: SAUPAN003751000
• symbol: msrR
• pan gene symbol^?: msrR
• synonym:
• product: peptide methionine sulfoxide reductase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SA1195 [new locus tag: SA_RS06795 ]
• symbol: msrR
• product: peptide methionine sulfoxide reductase
• replicon: chromosome
• strand: +
• coordinates: 1366983..1367966
• length: 984
• essential: no DEG other strains

⊟Accession numbers

• Gene ID: 1124033 NCBI
• RefSeq: NP_374475 NCBI
• BioCyc: see SA_RS06795
• MicrobesOnline: 103501 MicrobesOnline

⊟Phenotype

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⊟DNA sequence

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  ATGGATAAAGAAACTAATGACAACGAATATAGACGTCAAAGTGAACATCGCACTTCGGCG
  CCTAAGCGAAAAAAGAAGAAGAAAATTAGGAAATTACCTATCATTCTTCTGATTGTTGTA
  ATTTTACTTATCGCATTAGTTGTATATATTGTACATAGTTACAATAGCGGTGTAGAATAT
  GCCAAGAAACATGCGAAAGATGTTAAAGTACATCAATTTAATGGACCAGTAAAAAATGAT
  GGTAAAATTTCTATTCTTGTACTCGGTGCAGATAAAGCACAAGGTGGACAATCAAGAACA
  GATTCTATCATGGTTGTTCAATATGACTTTATCAATAAAAAAATGAAAATGATGTCTGTC
  ATGCGTGATATTTATGCAGATATTCCAGGATATGGAAAACACAAAATTAATTCAGCATAC
  GCTTTAGGTGGTCCAGAGCTACTTAGAAAAACACTTGATAAAAATTTAGGAATTAATCCT
  GAATATTATGCAGTAGTTGATTTTACTGGATTTGAGAAAATGATTGATGAATTAATGCCA
  GAAGGTGTACCAATTAATGTCGAAAAGGATATGTCGAAAAATATTGGTGTATCTTTGAAA
  AAGGGTAACCATAGGTTGAATGGTAAAGAATTACTTGGTTATGCAAGATTCCGTCACGAC
  CCTGAAGGTGACTTCGGACGCGTGCGACGTCAGCAACAAGTGATGCAAACATTGAAAAAA
  GAAATGGTTAATTTTAGAACAGTTGTTAAATTACCAAAAGTTGCAGGTATTTTAAGAGGC
  TATGTGAATACAAACATTCCTGATTCAGGGATTTTCCAAACAGGTTTGAGTTTTGGCATC
  CGAGGTGAAAAAGATGTTAAGTCATTGACTGTGCCAATCAAGAACTCATACGAAGATGTC
  AATACAAATACTGATGGTAGTGCATTACAGATTAATAAAAACACAAATAAACAAGCTATT
  AAAGACTTTTTAGATGAAGATTAA
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⊟Protein

⊟General

• locus tag: SA1195 [new locus tag: SA_RS06795 ]
• symbol: MsrR
• description: peptide methionine sulfoxide reductase
• length: 327
• theoretical pI: 10.2483
• theoretical MW: 36970.5
• GRAVY: -0.514679

⊟Function

• TIGRFAM:
  Signal transduction Regulatory functions Other cell envelope-related function transcriptional attenuator common domain (TIGR00350; HMM-score: 117.4)
  and 3 more
  Genetic information processing Protein fate Protein and peptide secretion and trafficking type VII secretion protein EssA (TIGR03927; HMM-score: 15)
  Cellular processes Cellular processes Pathogenesis type II secretion system protein G (TIGR01710; HMM-score: 8.2)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking type II secretion system protein G (TIGR01710; HMM-score: 8.2)
• TheSEED  :
  • Peptide methionine sulfoxide reductase regulator MsrR
  Regulation and Cell signaling Regulation and Cell signaling - no subcategory Cell envelope-associated LytR-CpsA-Psr transcriptional attenuators  Peptide methionine sulfoxide reductase regulator MsrR
• PFAM:
  no clan defined LytR_cpsA_psr; Cell envelope-related transcriptional attenuator domain (PF03816; HMM-score: 170.4)
  and 7 more
  DUF929; Domain of unknown function (DUF929) (PF06053; HMM-score: 16)
  DUF3671; Protein of unknown function (PF12420; HMM-score: 15.4)
  DUF5383; Family of unknown function (DUF5383) (PF17355; HMM-score: 15)
  Zn_Beta_Ribbon (CL0167) DUF2116; Uncharacterized protein containing a Zn-ribbon (DUF2116) (PF09889; HMM-score: 14)
  no clan defined DUF1510; Protein of unknown function (DUF1510) (PF07423; HMM-score: 12.7)
  Orf78; Orf78 (ac78) (PF06024; HMM-score: 12.6)
  Baculo_11_kDa; Baculovirus 11 kDa family (PF06143; HMM-score: 9.9)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic Membrane
  • Cytoplasmic Score: 0.17
  • Cytoplasmic Membrane Score: 9.51
  • Cellwall Score: 0.16
  • Extracellular Score: 0.15
  • Internal Helix: 1
• LocateP: N-terminally anchored (No CS)
  • Prediction by SwissProt Classification: Membrane
  • Pathway Prediction: Sec-(SPI)
  • Intracellular possibility: 0.17
  • Signal peptide possibility: -0.5
  • N-terminally Anchored Score: 7
  • Predicted Cleavage Site: No CleavageSite
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.057495
  • TAT(Tat/SPI): 0.000446
  • LIPO(Sec/SPII): 0.002712
• predicted transmembrane helices (TMHMM): 1

⊟Accession numbers

• GI: 15926942 NCBI
• RefSeq: NP_374475 NCBI
• UniProt: Q99Q02 UniProt

⊟Protein sequence

• MDKETNDNEYRRQSEHRTSAPKRKKKKKIRKLPIILLIVVILLIALVVYIVHSYNSGVEYAKKHAKDVKVHQFNGPVKNDGKISILVLGADKAQGGQSRTDSIMVVQYDFINKKMKMMSVMRDIYADIPGYGKHKINSAYALGGPELLRKTLDKNLGINPEYYAVVDFTGFEKMIDELMPEGVPINVEKDMSKNIGVSLKKGNHRLNGKELLGYARFRHDPEGDFGRVRRQQQVMQTLKKEMVNFRTVVKLPKVAGILRGYVNTNIPDSGIFQTGLSFGIRGEKDVKSLTVPIKNSYEDVNTNTDGSALQINKNTNKQAIKDFLDED

⊟Experimental data

• experimentally validated: data available for COL, NCTC8325
• protein localization: data available for COL
• quantitative data / protein copy number per cell:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: no polycistronic organisation predicted

⊟Regulation

• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications