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NCBI: 26-AUG-2013

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus N315
  • locus tag: SA1591 [new locus tag: SA_RS08965 ]
  • pan locus tag?: SAUPAN004463000
  • symbol: SA1591
  • pan gene symbol?: arsR
  • synonym:
  • product: hypothetical protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SA1591 [new locus tag: SA_RS08965 ]
  • symbol: SA1591
  • product: hypothetical protein
  • replicon: chromosome
  • strand: +
  • coordinates: 1830824..1831138
  • length: 315
  • essential: no DEG other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    ATGACGTATAAAGAACTAGCAACATTTTTAAAAGTTTTATCAGATTCAAGCAGATTAGAA
    ATACTAGATTTACTTTCTTGTGGAGAGTTATGCGCTTGTGATTTGTTAGCACATTTTCAA
    TTCTCTCAACCCACACTTAGCTATCATTTGAAAGCATTAGTAAAAACCAACTTAGTTACG
    ACACGAAAAATCGGAAATAAACATTTATACCAGCTTAATCATAATATTTTTGAGTCCGTA
    ATTAATAACTTGTCTAAGGTTCATACCTCTAACCAACGATGTTTTTGTCATAACCTTAAG
    ACTGGTGAATGCTAA
    60
    120
    180
    240
    300
    315

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SA1591 [new locus tag: SA_RS08965 ]
  • symbol: SA1591
  • description: hypothetical protein
  • length: 104
  • theoretical pI: 8.38639
  • theoretical MW: 11856.7
  • GRAVY: -0.0759615

⊟Function[edit | edit source]

  • TIGRFAM:
    Signal transduction Regulatory functions DNA interactions CRISPR locus-related DNA-binding protein (TIGR01884; HMM-score: 13.6)
  • TheSEED  :
    • Arsenical resistance operon repressor
    Virulence, Disease and Defense Resistance to antibiotics and toxic compounds Arsenic resistance  Arsenical resistance operon repressor
  • PFAM:
    HTH (CL0123) HTH_5; Bacterial regulatory protein, arsR family (PF01022; HMM-score: 59.7)
    and 6 more
    HTH_20; Helix-turn-helix domain (PF12840; HMM-score: 42.3)
    MarR_2; MarR family (PF12802; HMM-score: 19.9)
    MarR; MarR family (PF01047; HMM-score: 14.6)
    HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 13)
    Dimerisation2; Dimerisation domain (PF16864; HMM-score: 12.9)
    TrmB; Sugar-specific transcriptional regulator TrmB (PF01978; HMM-score: 12.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors: Arsenate; Arsenite
  • genes regulated by ArsR*, TF important in Arsenic resistanceRegPrecise
    repression
    arsR* > arsB*

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • LocateP: Intracellular
    • Prediction by SwissProt Classification: Cytoplasmic
    • Pathway Prediction: No pathway
    • Intracellular possibility: 1
    • Signal peptide possibility: -1
    • N-terminally Anchored Score: -1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.024512
    • TAT(Tat/SPI): 0.003316
    • LIPO(Sec/SPII): 0.064463
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MTYKELATFLKVLSDSSRLEILDLLSCGELCACDLLAHFQFSQPTLSYHLKALVKTNLVTTRKIGNKHLYQLNHNIFESVINNLSKVHTSNQRCFCHNLKTGEC

⊟Experimental data[edit | edit source]

  • experimentally validated:
  • protein localization:
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: ArsR* (repression) regulon
    ArsR*(TF)important in Arsenic resistance; RegPrecise 

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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