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⊟Summary[edit | edit source]
- pan ID?: SAUPAN001175000
- symbol?: esxA
- synonym:
- description?: virulence factor EsxA
- virulence factor EsxA
- putative WxG domain protein
- WXG100 family type VII secretion effector EsxA
- ESAT-6/Esx family secreted protein EsxA/YukE
- ESAT-6/WXG100 family secreted protein EsxA/YukE
- proteins of 100 residues with WXG family protein
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 1443218..1443562
- synteny block?: BlockID0006940
- occurrence?: in 100% of 33 strains
esxA: VIIb-secreted apoptosis inhibitor virulence factor EsxA
EsxA is secreted through the Type VIIb/ESAT-6 secretion apparatus and inhibits host cell apoptosis.
The crystal structure of EsxA can be found at the Protein Data Bank: 2VRZ
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0282 (esxA)
08BA02176:
C248_0272 (esxA)
11819-97:
MS7_0273 (esxA)
6850:
RSAU_000228
71193:
ST398NM01_0297
ECT-R 2:
ECTR2_243
ED133:
SAOV_0225
ED98:
SAAV_0250
HO 5096 0412:
SAEMRSA15_02410
JH1:
SaurJH1_0273
JH9:
SaurJH9_0266
JKD6008:
SAA6008_00256 (esxA)
JKD6159:
SAA6159_00263 (esxA)
LGA251:
SARLGA251_02460 (esxA)
M013:
M013TW_0263
MRSA252:
SAR0279
MSHR1132:
SAMSHR1132_02500
MSSA476:
SAS0258
Mu3:
SAHV_0280
Mu50:
SAV0282
MW2:
MW0258
RF122:
SAB0223
ST398:
SAPIG0297
T0131:
SAT0131_00278
TCH60:
HMPREF0772_10218 (esxA)
TW20:
SATW20_02840 (esxA)
USA300_TCH1516:
USA300HOU_0297 (esxA)
VC40:
SAVC_01160
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MAMIKMSPEEIRAKSQSYGQGSDQIRQILSDLTRAQGEIAANWEGQAFSRFEEQFQQLSP
N315 MAMIKMSPEEIRAKSQSYGQGSDQIRQILSDLTRAQGEIAANWEGQAFSRFEEQFQQLSP
NCTC8325 MAMIKMSPEEIRAKSQSYGQGSDQIRQILSDLTRAQGEIAANWEGQAFSRFEEQFQQLSP
Newman MAMIKMSPEEIRAKSQSYGQGSDQIRQILSDLTRAQGEIAANWEGQAFSRFEEQFQQLSP
USA300_FPR3757 MAMIKMSPEEIRAKSQSYGQGSDQIRQILSDLTRAQGEIAANWEGQAFSRFEEQFQQLSP
************************************************************
COL KVEKFAQLLEEIKQQLNSTADAVQEQDQQLSNNFGLQ
N315 KVEKFAQLLEEIKQQLNSTADAVQEQDQQLSNNFGLQ
NCTC8325 KVEKFAQLLEEIKQQLNSTADAVQEQDQQLSNNFGLQ
Newman KVEKFAQLLEEIKQQLNSTADAVQEQDQQLSNNFGLQ
USA300_FPR3757 KVEKFAQLLEEIKQQLNSTADAVQEQDQQLSNNFGLQ
*************************************
- ↑ Charalampia G Korea, Giuliana Balsamo, Alfredo Pezzicoli, Christina Merakou, Simona Tavarini, Fabio Bagnoli, Davide Serruto, Meera Unnikrishnan
Staphylococcal Esx proteins modulate apoptosis and release of intracellular Staphylococcus aureus during infection in epithelial cells.
Infect Immun: 2014, 82(10);4144-53
[PubMed:25047846] [WorldCat.org] [DOI] (I p)