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NCBI: 10-JUN-2013
⊟Summary[edit | edit source]
- organism: Staphylococcus aureus USA300_FPR3757
- locus tag: SAUSA300_0278 [new locus tag: SAUSA300_RS01490 ]
- pan locus tag?: SAUPAN001175000
- symbol: SAUSA300_0278
- pan gene symbol?: esxA
- synonym:
- product: hypothetical protein
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SAUSA300_0278 [new locus tag: SAUSA300_RS01490 ]
- symbol: SAUSA300_0278
- product: hypothetical protein
- replicon: chromosome
- strand: +
- coordinates: 330521..330814
- length: 294
- essential: unknown other strains
⊟Accession numbers[edit | edit source]
- Gene ID: 3914717 NCBI
- RefSeq: YP_492992 NCBI
- BioCyc: see SAUSA300_RS01490
- MicrobesOnline: 1291793 MicrobesOnline
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
- 1
61
121
181
241ATGGCAATGATTAAGATGAGTCCAGAGGAAATCAGAGCAAAATCGCAATCTTACGGGCAA
GGTTCAGACCAAATCCGTCAAATTTTATCTGATTTAACACGTGCACAAGGTGAAATTGCA
GCGAACTGGGAAGGTCAAGCTTTCAGCCGTTTCGAAGAGCAATTCCAACAACTTAGTCCT
AAAGTAGAAAAATTTGCACAATTATTAGAAGAAATTAAACAACAATTGAATAGCACTGCT
GATGCCGTTCAAGAACAAGACCAACAACTTTCTAATAATTTCGGTTTGCAATAA60
120
180
240
294
⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SAUSA300_0278 [new locus tag: SAUSA300_RS01490 ]
- symbol: SAUSA300_0278
- description: hypothetical protein
- length: 97
- theoretical pI: 4.32285
- theoretical MW: 11036.2
- GRAVY: -0.765979
⊟Function[edit | edit source]
- TIGRFAM: WXG100 family type VII secretion target (TIGR03930; HMM-score: 80.2)and 4 moretype VII secretion effector, TIGR04197 family (TIGR04197; HMM-score: 20.8)two transmembrane protein (TIGR04527; HMM-score: 18.8)putative zinc finger/helix-turn-helix protein, YgiT family (TIGR03830; HMM-score: 13.3)Protein fate Protein folding and stabilization prefoldin, alpha subunit (TIGR00293; HMM-score: 10.3)
- TheSEED :
- 6 kDa early secretory antigenic target ESAT-6 (EsxA)
- PFAM: EsxAB (CL0352) WXG100; Proteins of 100 residues with WXG (PF06013; HMM-score: 78.1)and 28 moreT7SS_ESX_EspC; Excreted virulence factor EspC, type VII ESX diderm (PF10824; HMM-score: 19.3)no clan defined Apolipoprotein; Apolipoprotein A1/A4/E domain (PF01442; HMM-score: 18.7)EzrA; Septation ring formation regulator, EzrA (PF06160; HMM-score: 18.3)KxDL; Uncharacterized conserved protein (PF10241; HMM-score: 18.3)DUF2130; Uncharacterized protein conserved in bacteria (DUF2130) (PF09903; HMM-score: 17.4)IFT57; Intra-flagellar transport protein 57 (PF10498; HMM-score: 16.8)Med2; Mediator complex subunit 2 (PF11214; HMM-score: 16.6)TSNAXIP1_N; Translin-associated factor X-interacting N-terminus (PF15739; HMM-score: 16.6)Filament; Intermediate filament protein (PF00038; HMM-score: 15.9)Tup_N; Tup N-terminal (PF08581; HMM-score: 15.8)Cast; RIM-binding protein of the cytomatrix active zone (PF10174; HMM-score: 15.7)ING; Inhibitor of growth proteins N-terminal histone-binding (PF12998; HMM-score: 15.1)Phage_30_3; Bacteriophage protein GP30.3 (PF08010; HMM-score: 15)DNA_repr_REX1B; DNA repair REX1-B (PF14966; HMM-score: 15)LXG; LXG domain of WXG superfamily (PF04740; HMM-score: 14.8)Mobilization_B; Mobilization protein B (PF17511; HMM-score: 14.8)PDDEXK (CL0236) RmuC; RmuC family (PF02646; HMM-score: 14.7)no clan defined CK2S; Casein Kinase 2 substrate (PF15011; HMM-score: 14.6)TRPM_tetra; Tetramerisation domain of TRPM (PF16519; HMM-score: 14.6)DUF5344; Family of unknown function (DUF5344) (PF17279; HMM-score: 14.6)Skp1; Skp1 family, dimerisation domain (PF01466; HMM-score: 13.6)Cytochrom_B562; Cytochrome b562 (PF07361; HMM-score: 12.6)MscS_porin; Mechanosensitive ion channel porin domain (PF12795; HMM-score: 11.9)OML_zippers (CL0590) LPP; Lipoprotein leucine-zipper (PF04728; HMM-score: 11.7)no clan defined UPF0449; Uncharacterised protein family UPF0449 (PF15136; HMM-score: 11.7)FapA; Flagellar Assembly Protein A (PF03961; HMM-score: 10.8)TMPIT; TMPIT-like protein (PF07851; HMM-score: 10.5)KNOX2; KNOX2 domain (PF03791; HMM-score: 10.3)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Extracellular
- Cytoplasmic Score: 0
- Cytoplasmic Membrane Score: 0
- Cellwall Score: 0
- Extracellular Score: 10
- Internal Helices: 0
- LocateP: Intracellular
- Prediction by SwissProt Classification: Cytoplasmic
- Pathway Prediction: No pathway
- Intracellular possibility: 1
- Signal peptide possibility: -1
- N-terminally Anchored Score: -1
- Predicted Cleavage Site: No CleavageSite
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.005097
- TAT(Tat/SPI): 0.000636
- LIPO(Sec/SPII): 0.001053
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MAMIKMSPEEIRAKSQSYGQGSDQIRQILSDLTRAQGEIAANWEGQAFSRFEEQFQQLSPKVEKFAQLLEEIKQQLNSTADAVQEQDQQLSNNFGLQ
⊟Experimental data[edit | edit source]
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
- MicrobesOnline: no polycistronic organisation predicted
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription pattern[edit | edit source]
- S.aureus Expression Data Browser: data available for NCTC8325
⊟Protein synthesis (provided by Aureolib)[edit | edit source]
⊟Protein stability[edit | edit source]
- half-life: no data available
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You are kindly invited to share additional interesting facts.