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⊟Summary[edit | edit source]
- pan ID?: SAUPAN002591000
- symbol?: saeR
- synonym:
- description?: DNA-binding response regulator
- DNA-binding response regulator
- DNA-binding response regulator SaeR
- response regulator
- response regulator SaeR, putative
- response regulator transcription factor
- Response regulator SaeR
- response regulator protein
- response regulator receiver
- two component transcriptional regulator
- winged helix family two component transcriptional regulator
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 3104173..3104841
- synteny block?: BlockID0018270
- occurrence?: in 100% of 33 strains
saeR: S. aureus exoprotein expression response regulator [1]
• A crystal structure is available: 4QWQ
• SaeR has a consensus DNA binding motif of: 5'-TTAAYwwwwwRTTAA-3'
• The SaeR Regulon consists of Thirty-Three Genes
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0683 (saeR)
08BA02176:
C248_0790 (saeR)
11819-97:
MS7_0757 (saeR)
6850:
RSAU_000681 (saeR)
71193:
ST398NM01_0783
ECT-R 2:
ECTR2_657
ED133:
SAOV_0740c (saeR)
ED98:
SAAV_0668 (saeR)
HO 5096 0412:
SAEMRSA15_06320 (saeR)
JH1:
SaurJH1_0746
JH9:
SaurJH9_0730
JKD6008:
SAA6008_00722 (saeR)
JKD6159:
SAA6159_00661 (saeR)
LGA251:
SARLGA251_06390 (saeR)
M013:
M013TW_0692
MRSA252:
SAR0759 (saeR)
MSHR1132:
SAMSHR1132_06510
MSSA476:
SAS0671
Mu3:
SAHV_0703 (saeR)
Mu50:
SAV0706 (saeR)
MW2:
MW0668 (saeR)
RF122:
SAB0655c (saeR)
ST398:
SAPIG0783
T0131:
SAT0131_00776
TCH60:
HMPREF0772_12481 (saeR)
TW20:
SATW20_07810 (saeR)
USA300_TCH1516:
USA300HOU_0729 (saeR)
VC40:
SAVC_03165
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MTHLLIVDDEQDIVDICQTYFEYEGYKVTTTTSGKEAISLLSNDIDIMVLDIMMPEVNGY
N315 MTHLLIVDDEQDIVDICQTYFEYEGYKVTTTTSGKEAISLLSNDIDIMVLDIMMPEVNGY
NCTC8325 MTHLLIVDDEQDIVDICQTYFEYEGYKVTTTTSGKEAISLLSNDIDIMVLDIMMPEVNGY
Newman MTHLLIVDDEQDIVDICQTYFEYEGYKVTTTTSGKEAISLLSNDIDIMVLDIMMPEVNGY
USA300_FPR3757 MTHLLIVDDEQDIVDICQTYFEYEGYKVTTTTSGKEAISLLSNDIDIMVLDIMMPEVNGY
************************************************************
COL DIVKEMKRQKLDIPFIYLTAKTQEHDTIYALTLGADDYVKKPFSPRELVLRINNLLTRMK
N315 DIVKEMKRQKLDIPFIYLTAKTQEHDTIYALTLGADDYVKKPFSPRELVLRINNLLTRMK
NCTC8325 DIVKEMKRQKLDIPFIYLTAKTQEHDTIYALTLGADDYVKKPFSPRELVLRINNLLTRMK
Newman DIVKEMKRQKLDIPFIYLTAKTQEHDTIYALTLGADDYVKKPFSPRELVLRINNLLTRMK
USA300_FPR3757 DIVKEMKRQKLDIPFIYLTAKTQEHDTIYALTLGADDYVKKPFSPRELVLRINNLLTRMK
************************************************************
COL KYHHQPVEQLSFDELTLINLSKVVTVNGHEVPMRIKEFELLWYLASRENEVISKSELLEK
N315 KYHHQPVEQLSFDELTLINLSKVVTVNGHEVPMRIKEFELLWYLASRENEVISKSELLEK
NCTC8325 KYHHQPVEQLSFDELTLINLSKVVTVNGHEVPMRIKEFELLWYLASRENEVISKSELLEK
Newman KYHHQPVEQLSFDELTLINLSKVVTVNGHEVPMRIKEFELLWYLASRENEVISKSELLEK
USA300_FPR3757 KYHHQPVEQLSFDELTLINLSKVVTVNGHEVPMRIKEFELLWYLASRENEVISKSELLEK
************************************************************
COL VWGYDYYEDANTVNVHIHRIREKLEKESFTTYTITTVWGLGYKFERSR
N315 VWGYDYYEDANTVNVHIHRIREKLEKESFTTYTITTVWGLGYKFERSR
NCTC8325 VWGYDYYEDANTVNVHIHRIREKLEKESFTTYTITTVWGLGYKFERSR
Newman VWGYDYYEDANTVNVHIHRIREKLEKESFTTYTITTVWGLGYKFERSR
USA300_FPR3757 VWGYDYYEDANTVNVHIHRIREKLEKESFTTYTITTVWGLGYKFERSR
************************************************
- ↑ Lisa Bleul, Patrice Francois, Christiane Wolz
Two-Component Systems of S. aureus: Signaling and Sensing Mechanisms.
Genes (Basel): 2021, 13(1);
[PubMed:35052374] [WorldCat.org] [DOI] (I e)Augustus Pendleton, Won-Sik Yeo, Shahad Alqahtani, Dennis A DiMaggio, Carl J Stone, Zhaotao Li, Vineet K Singh, Christopher P Montgomery, Taeok Bae, Shaun R Brinsmade
Regulation of the Sae Two-Component System by Branched-Chain Fatty Acids in Staphylococcus aureus.
mBio: 2022, 13(5);e0147222
[PubMed:36135382] [WorldCat.org] [DOI] (I p)Dereje D Gudeta, Mei G Lei, Chia Y Lee
Contribution of hla Regulation by SaeR to Staphylococcus aureus USA300 Pathogenesis.
Infect Immun: 2019, 87(9);
[PubMed:31209148] [WorldCat.org] [DOI] (I e)Qian Liu, Won-Sik Yeo, Taeok Bae
The SaeRS Two-Component System of Staphylococcus aureus.
Genes (Basel): 2016, 7(10);
[PubMed:27706107] [WorldCat.org] [DOI] (P e)