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⊟Summary[edit | edit source]
- pan ID?: SAUPAN003193000
- symbol?: ltaA
- synonym:
- description?: MFS transporter
- MFS transporter
- glycolipid permease LtaA, putative
- Glycolipid permease ltaA
- major facilitator superfamily transporter
- major facilitator transporter
- membrane protein
- MFS family major facilitator transporter
- MFS-type transporter
- Permease
- putative glycolipid permease ltaA
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 3585331..3586113
- synteny block?: BlockID0022800
- occurrence?: in 100% of 34 strains
ltaA : diglucosyl-diacylglycerol flippase [1]
• A crystal structure is available : 6S7V
Transfer of diglucosyl-diacylglycerol from the inner leaflet of the cell membrane to the outer leaflet by diglucosyl-diacylglycerol flippase is the second committed step in teichoic acid synthesis. This activity is primarily regulated by binding of the coordination of zonal exclusion proteins CozEa and CozEb which inhibit the flippase activity. All subsequent lipoteichoic acid biosynthesis and modification steps will occur in the extracellular environment.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0970
08BA02176:
C248_1040
11819-97:
MS7_0971 (ltaA)
6850:
RSAU_000901 (ltaA)
71193:
ST398NM01_1011
ECT-R 2:
ECTR2_870
ED133:
SAOV_0961c
ED98:
SAAV_0978
HO 5096 0412:
SAEMRSA15_08460
JH1:
SaurJH1_1033
JH9:
SaurJH9_1014
JKD6008:
SAA6008_00971
JKD6159:
SAA6159_00872
LGA251:
SARLGA251_09310
M013:
M013TW_0940
MRSA252:
SAR0986
MSHR1132:
SAMSHR1132_08630
MSSA476:
SAS0885
Mu3:
SAHV_1010
Mu50:
SAV1016
MW2:
MW0897
RF122:
SAB0882c
ST398:
SAPIG1011
T0131:
SAT0131_01051
TCH60:
HMPREF0772_12218
TW20:
SATW20_10130
USA300_TCH1516:
USA300HOU_0974
VC40:
SAVC_04245
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 | |
| JSNZ |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.505)
COL ------MQDSSLNNYANHKNFILMLIILFLMEFARGMYILSYINFLPTVTSIAVAITSLA
N315 ------MQDSSLNNYANHKNFILMLIILFLMEFARGMYILSYINFLPTVTSIAVAITSLA
NCTC8325 MERFLYMQDSSLNNYANHKNFILMLIILFLMEFARGMYILSYINFLPTVTSIAVAITSLA
Newman ------MQDSSLNNYANHKNFILMLIILFLMEFARGMYILSYINFLPTVTSIAVAITSLA
USA300_FPR3757 MERFLYMQDSSLNNYANHKNFILMLIILFLMEFARGMYILSYINFLPTVTSIAVAITSLA
JSNZ ------MQDSSLNNYANHKNFILMLIILFLMEFARGMYILSYINFLPTVTSIAVAITSLA
******************************************************
COL FSIHFIADASTNFVIGFLLKKFGTKIVLTTGFILAFTSLFLVIWFPASPFVIIFSAMMLG
N315 FSIHFIADASTNFVIGFLLKKFGTKIVLTTGFILAFTSLFLVIWFPASPFVIIFSAMMLG
NCTC8325 FSIHFIADASTNFVIGFLLKKFGTKIVLTTGFILAFTSLFLVIWFPASPFVIIFSAMMLG
Newman FSIHFIADASTNFVIGFLLKKFGTKIVLTTGFILAFTSLFLVIWFPASPFVIIFSAMMLG
USA300_FPR3757 FSIHFIADASTNFVIGFLLKKFGTKIVLTTGFILAFTSLFLVIWFPASPFVIIFSAMMLG
JSNZ FSIHFIADASTNFVIGFLLKKFGTKIVLTTGFILAFTSLFLVIWFPASPFVIIFSAMMLG
************************************************************
COL IAVSPIWVIMLSSVEEDKRGKQMGYVYFSWLLGLLVGMVFMNLLIKVHPTRFAFMMSLVV
N315 IAVSPIWVIMLSSVEEDKRGKQMGYVYFSWLLGLLVGMVFMNLLIKVHPTRFAFMMSLVV
NCTC8325 IAVSPIWVIMLSSVEEDKRGKQMGYVYFSWLLGLLVGMVFMNLLIKVHPTRFAFMMSLVV
Newman IAVSPIWVIMLSSVEEDKRGKQMGYVYFSWLLGLLVGMVFMNLLIKVHPTRFAFMMSLVV
USA300_FPR3757 IAVSPIWVIMLSSVEEDKRGKQMGYVYFSWLLGLLVGMVFMNLLIKVHPTRFAFMMSLVV
JSNZ IAVSPIWVIMLSSVEEDKRGKQMGYVYFSWLLGLLVGMVFMNLLIKVHPTRFAFMMSLVV
************************************************************
COL LIAWILYYFVDVKLTNYNTRPVKAQLRQIVDVTKRHLLLFPGILLQGAAIAALVPILPTY
N315 LIAWILYYFVDVKLTNYNTRPVKAQLRQIVDVTKRHLLLFPGILLQGAAIAALVPILPTY
NCTC8325 LIAWILYYFVDVKLTNYNTRPVKAQLRQIVDVTKRHLLLFPGILLQGAAIAALVPILPTY
Newman LIAWILYYFVDVKLTNYNTRPVKAQLRQIVDVTKRHLLLFPGILLQGAAIAALVPILPTY
USA300_FPR3757 LIAWILYYFVDVKLTNYNTRPVKAQLRQIVDVTKRHLLLFPGILLQGAAIAALVPILPTY
JSNZ LIAWILYYFVDVKLTNYNTRPVKAQLRQIVDVTKRHLLLFPGILLQGAAIAALVPILPTY
************************************************************
COL ATKVINVSTIEYTVAIIIGGIGCAVSMLFLSKLIDNRSRNFMYGVILSGFILYMILIFTL
N315 ATKVINVSTIEYTVAIIIGGIGCAVSMLFLSKLIDNRSRNFMYGVILSGFILYMILIFTL
NCTC8325 ATKVINVSTIEYTVAIIIGGIGCAVSMLFLSKLIDNRSRNFMYGVILSGFILYMILIFTL
Newman ATKVINVSTIEYTVAIIIGGIGCAVSMLFLSKLIDNRSRNFMYGVILSGFILYMILIFTL
USA300_FPR3757 ATKVINVSTIEYTVAIIIGGIGCAVSMLFLSKLIDNRSRNFMYGVILSGFILYMILIFTL
JSNZ ATKVINVSTIEYTVAIIIGGIGCAVSMLFLSKLIDNRSRNFMYGVILSGFILYMILIFTL
************************************************************
COL SMIVNIHILWIIALAIGLMYGILLPAWNTFMARFIKSDEQEETWGVFNSIQGFGSMIGPL
N315 SMIVNIHIVWIIALAIGLMYGILLPAWNTFMARFIKSDEQEETWGVFNSIQGFGSMIGPL
NCTC8325 SMIVNIHILWIIALAIGLMYGILLPAWNTFMARFIKSDEQEETWGVFNSIQGFGSMIGPL
Newman SMIVNIHILWIIALAIGLMYGILLPAWNTFMARFIKSDEQEETWGVFNSIQGFGSMIGPL
USA300_FPR3757 SMIVNIHILWIIALAIGLMYGILLPAWNTFMARFIKSDEQEETWGVFNSIQGFGSMIGPL
JSNZ SMIVNIHIVWIIALAIGLMYGILLPAWNTFMARFIKSDEQEETWGVFNSIQGFGSMIGPL
********:***************************************************
COL FGGLITQFTNNLNNTFYFSALIFLVLAVFYGSYFIVNREKAK
N315 FGGLITQFTNDLNNTFYFSALIFLVLAVFYGSYFIANREKAK
NCTC8325 FGGLITQFTNNLNNTFYFSALIFLVLAVFYGSYFIVNREKAK
Newman FGGLITQFTNNLNNTFYFSALIFLVLAVFYGSYFIVNREKAK
USA300_FPR3757 FGGLITQFTNNLNNTFYFSALIFLVLAVFYGSYFIVNREKAK
JSNZ FGGLITQFTNNLNNTFYFSALIFLVLAVFYGSYFIANREKAK
**********:************************.******
- ↑ Bing Zhang, Xue Liu, Elisabeth Lambert, Guillaume Mas, Sebastian Hiller, Jan-Willem Veening, Camilo Perez
Structure of a proton-dependent lipid transporter involved in lipoteichoic acids biosynthesis.
Nat Struct Mol Biol: 2020, 27(6);561-569
[PubMed:32367070] [WorldCat.org] [DOI] (I p)Maria Disen Barbuti, Elisabeth Lambert, Ine Storaker Myrbråten, Adrien Ducret, Gro Anita Stamsås, Linus Wilhelm, Xue Liu, Zhian Salehian, Jan-Willem Veening, Daniel Straume, Christophe Grangeasse, Camilo Perez, Morten Kjos
The function of CozE proteins is linked to lipoteichoic acid biosynthesis in Staphylococcus aureus.
mBio: 2024, 15(6);e0115724
[PubMed:38757970] [WorldCat.org] [DOI] (I p)Dora Bonini, Seána Duggan, Alaa Alnahari, Tarcisio Brignoli, Henrik Strahl, Ruth C Massey
Lipoteichoic acid biosynthesis by Staphylococcus aureus is controlled by the MspA protein.
mBio: 2024, 15(8);e0151224
[PubMed:39037275] [WorldCat.org] [DOI] (I p)