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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005722000
- symbol?: —
- synonym:
- description?: MarR family transcriptional regulator
- MarR family transcriptional regulator
- MarR family regulatory protein
- transcriptional regulator, putative
- winged helix DNA-binding protein
- HTH-type transcriptional regulator
- marR family protein
- transcriptional regulator, MarR family
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 5827475..5827915
- synteny block?: BlockID0044680
- occurrence?: in 100% of 34 strains
mepR2 : multidrug efflux pump 2 transcriptional repressor MepR2 [1]
• A crystal structure is available : 4EM1
There is some confusion in the S. aureus literature regarding the MepRA transporters. Multiple papers and two crystal structures are available referring to two separate operons as MepRA. For clarity, we will annotate the operon between the ascorbate phosphotransferase operon and the glycerol-3-phosphate transporter (3ECO) as "Mep1" and the one between femX and sarV (4EM1) as Mep2.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2203
08BA02176:
C248_2302
11819-97:
MS7_2284
6850:
RSAU_002099
71193:
ST398NM01_2316
ECT-R 2:
ECTR2_2126
ED133:
SAOV_2303
ED98:
SAAV_2328
HO 5096 0412:
SAEMRSA15_21630
JH1:
SaurJH1_2332
JH9:
SaurJH9_2290
JKD6008:
SAA6008_02302
JKD6159:
SAA6159_02170
LGA251:
SARLGA251_20490
M013:
M013TW_2223
MRSA252:
SAR2349
MSHR1132:
SAMSHR1132_20900
MSSA476:
SAS2155
Mu3:
SAHV_2249
Mu50:
SAV2265
MW2:
MW2183
RF122:
SAB2137
ST398:
SAPIG2316
T0131:
SAT0131_02440
TCH60:
HMPREF0772_10935
TW20:
SATW20_23970
USA300_TCH1516:
USA300HOU_2246 (marR)
VC40:
SAVC_10185
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 | |
| JSNZ |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.505)
COL MLSQEFFNSFITIYRPYLKLAEPILEKHNIYYGQWLILRDIAKHQPTTLIEISHRRAIEK
N315 MLSQEFFNSFITIYRPYLKLAEPILEKHNIYYGQWLILRDIAKHQPTTLIEISHRRAIEK
NCTC8325 MLSQEFFNSFITIYRPYLKLAEPILEKHNIYYGQWLILRDIAKHQPTTLIEISHRRAIEK
Newman MLSQEFFNSFITIYRPYLKLAEPILEKHNIYYGQWLILRDIAKHQPTTLIEISHRRAIEK
USA300_FPR3757 MLSQEFFNSFITIYRPYLKLAEPILEKHNIYYGQWLILRDIAKHQPTTLIEISHRRAIEK
JSNZ MLSQEFFNSFITIYRPYLKLAEPILEKHNIYYGQWLILRDIAKHQPTTLIEISHRRAIEK
************************************************************
COL PTARKTLKALIENDLITVENSLEDKRQKFLTLTPKGHELYEIVCLDVQKLQQAVVAKTNI
N315 PTARKTLKALIENDLITVENSLEDKRQKFLTLTPKGHELYEIVCLDVQKLQQAVVAKTNI
NCTC8325 PTARKTLKALIENDLITVENSLEDKRQKFLTLTPKGHELYEIVCLDVQKLQQAVVAKTNI
Newman PTARKTLKALIENDLITVENSLEDKRQKFLTLTPKGHELYEIVCLDVQKLQQAVVAKTNI
USA300_FPR3757 PTARKTLKALIENDLITVENSLEDKRQKFLTLTPKGHELYEIVCLDVQKLQQAVVAKTNI
JSNZ PTARKTLKALIENDLITVENSLEDKRQKFLTLTPKGHELYEIVCLDVQKLQQAVVAKTNI
************************************************************
COL SQDQMQETINVMNQIHEILLKEAHND
N315 SQDQMQETINVMNQIHEILLKEAHND
NCTC8325 SQDQMQETINVMNQIHEILLKEAHND
Newman SQDQMQETINVMNQIHEILLKEAHND
USA300_FPR3757 SQDQMQETINVMNQIHEILLREAHND
JSNZ SQDQMQETINVMNQIHEILLKEAHND
********************:*****
- ↑ Muthiah Kumaraswami, Jason T Schuman, Susan M Seo, Glenn W Kaatz, Richard G Brennan
Structural and biochemical characterization of MepR, a multidrug binding transcription regulator of the Staphylococcus aureus multidrug efflux pump MepA.
Nucleic Acids Res: 2009, 37(4);1211-24
[PubMed:19129225] [WorldCat.org] [DOI] (I p)Ivan Birukou, Nam K Tonthat, Susan M Seo, Bryan D Schindler, Glenn W Kaatz, Richard G Brennan
The molecular mechanisms of allosteric mutations impairing MepR repressor function in multidrug-resistant strains of Staphylococcus aureus.
mBio: 2013, 4(5);e00528-13
[PubMed:23982071] [WorldCat.org] [DOI] (I e)Ivan Birukou, Susan M Seo, Bryan D Schindler, Glenn W Kaatz, Richard G Brennan
Structural mechanism of transcription regulation of the Staphylococcus aureus multidrug efflux operon mepRA by the MarR family repressor MepR.
Nucleic Acids Res: 2014, 42(4);2774-88
[PubMed:24293644] [WorldCat.org] [DOI] (I p)