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Summary[edit | edit source]

  • pan ID?: SAUPAN006071000
  • symbol?:
  • synonym:
  • description?: Insertion sequenceATP-binding protein

      descriptions from strain specific annotations:

    • Insertion sequenceATP-binding protein
    • Insertion sequenceATP-binding protein, putative
    • membrane protein
    • pseudogene
  • strand?: -
  • coordinates?: 6116259..6117533
  • synteny block?: BlockID0048120
  • occurrence?: in 68% of 34 strains

tslBψ : Type VII-secreted phospholipase toxin TslB pseudogene [1]

TslB is a paralog of the type VII-secreted phospholipase toxin TslA. Staphylococci may encode as many as three TslA paralogs although frequently all are deactivated by frameshift mutation except for one. In a 2023 survey of sequenced Staphylococcus aureus genomes, 78% of isolates encode a full-length TslA, 41% a full-length TslB and 13% a full-length TslC.

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    JSNZ:
    04-02981:
    SA2981_2421
    08BA02176:
    C248_2542
    11819-97:
    6850:
    RSAU_002323
    71193:
    ST398NM01_2541
    ECT-R 2:
    ECTR2_2341
    ED133:
    SAOV_2531c
    ED98:
    SAAV_2550
    HO 5096 0412:
    SAEMRSA15_23840
    JH1:
    SaurJH1_2563
    JH9:
    SaurJH9_2511
    JKD6008:
    JKD6159:
    SAA6159_02380
    LGA251:
    M013:
    M013TW_2445
    MRSA252:
    MSHR1132:
    MSSA476:
    Mu3:
    SAHV_2468
    Mu50:
    SAV2484
    MW2:
    RF122:
    SAB2367c
    ST398:
    SAPIG2541
    T0131:
    TCH60:
    TW20:
    USA300_TCH1516:
    USA300HOU_2476
    VC40:

Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757
JSNZ

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.505)


    COL             MSQTEYQIKSGNIKGNSEETSTVSNISYEIENANNSGLKQNKIDKQIKKLQEKNKFPKNL
    N315            MNKTKYQINSDNIKSNSEETSAISSISYEIENANNNDLNNASIQTQIEILKSQNSFPKNL
    Newman          MSQTEYQIKSGNIKGNSEETSTVSNISYEIENANNSGLKQNKIDKQIKKLQEKNKFPKNL
    JSNZ            MSQTEYQIKPDNITSNSEETSTISKISYEIENANNSGLKKRKIDTQIEVFKEKGKFPKNL
                    *.:*:***:..**..******::*.**********..*:: .*:.**: ::.:..*****

    COL             SYLKSYTDPKTGTTTSAFLNKDTGKVTLGMTGTNVHKDAILKQTFGVPSYQGYIDVSETL
    N315            SYLKSYTDPKTGTTTSAFLNKDTGKVTLGMTGTNVHKDAILKQTFGVPSYQGYIDASETL
    Newman          SYLKSYTDPKTGTTTSAFLNKDTGKVTLGMTGTNVHKDAILKQTFGVPSYQGYIDVSETL
    JSNZ            KYVDSYTDPKTGTTTSAFLNKETGKVTLGMTGTNVHKDAIFKKTLGIASSQDNRDASETL
                    .*:.*****************:******************:*:*:*:.* *.  *.****

    COL             KDIGADVNIGLHSVTDKDPHYKNTQDFIKNIKKDYDIDIITGHSLGGRDAMILGMSNDIK
    N315            KDIGADVNIGLHSVTDKDPHYKNTQDFIKNIKKDYDIDIITGHSLGGRDAMILGMSNDIK
    Newman          KDIGADVNIGLHSVTDKDPHYKNTQDFIKNIKKDYDIDIITGHSLGGRDAMILGMSNDIK
    JSNZ            KDIGADVNIGLHSVTDKDPHYKNTQDFIKNIKKDYDIDIITGHSLGGRDAMILGMSNDIK
                    ************************************************************

    COL             HIVVYNPAPLAIKDVSGLYADQEELKKLIEKYDGHIVRFVSDEDELDAGVRNHLYETAGE
    N315            HIVVYNPAPLAIKDVSGLYADQEELKKLIEKYDGHIVRFVSDEDELDAGVRNHLYETAGE
    Newman          HIVVYNPAPLAIKDVSGLYADQEELKKLIEKYDGHIVRFVSDEDELDAGVRNHLYETAGE
    JSNZ            HIVVYNPAPLAIKDVSGLYADQEELKKLIEKYDGHIVRFVSDEDELDADVRNHLYETAGE
                    ************************************************.***********

    COL             KIVLKNGEGHAMSGILMSRTQAIILAELNKVKGYQDENNKALKSVRKQTRHRLHKVETLR
    N315            KIVLKNGEGHAMSGILMSRTQAIILAELNKVKGYQDENNKALKSVRKQTRHRLHKVETLR
    Newman          KIVLKNGEGHAMSGILMSRTQAIILAELNKVKGYQDENNKALKSVRKQTRHRLHKVETLR
    JSNZ            KIVLKNGEGHSMSGFLISGTQAIILAELNKVKGYQDENNKSLKSVRKQTRHRLHKVETLR
                    **********:***:*:* *********************:*******************

    COL             ANWIQTTGGSLSSSQQQLLEALTALTIAEGLNQLVNEESQHLKKCITRWHINLETTGKKR
    N315            ANWIQTTGGSLSSSQQQLLEALTALTIAEGLNQLVNEESQHLKK---MYHAMAHKFGDNW
    Newman          ANWIQTTGGSLSSSQQQLLEALTALTIAEGLNQLVNEESQHLKKCITRWHINLETTGKKR
    JSNZ            ANWIQTTGGSLSSSQQQLLEALTALTIAEGLNQLVNEESQHLKK---MYHAMAHKFGDNW
                    ********************************************    :*   .. *.: 

    COL             KKLE--------------------------------------------------------
    N315            KKAQEVGNEIGEKLTSEEVIDELRKGGAYESKLETDPKRKIDDKIKKLNDVYKNCNGYIA
    Newman          KKLE--------------------------------------------------------
    JSNZ            KKTQEVGNEIGEKLTSEEVIDELRKGGAYESKLETDPKRKIDDKIKKLNDVYKNCNGYIA
                    ** :                                                        

    COL             ------MKLVKN------------
    N315            KIKQSIEAIVSNDQMLASQIDGMM
    Newman          ------MKLVKN------------
    JSNZ            KIKQSIEAIVSNDQMLASQIDGMM
                            :*.*            

  1. Stephen R Garrett, Nicole Mietrach, Justin Deme, Alina Bitzer, Yaping Yang, Fatima R Ulhuq, Dorothee Kretschmer, Simon Heilbronner, Terry K Smith, Susan M Lea, Tracy Palmer
    A type VII-secreted lipase toxin with reverse domain arrangement.
    Nat Commun: 2023, 14(1);8438
    [PubMed:38114483] [WorldCat.org] [DOI] (I e)