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⊟Summary[edit | edit source]
- pan ID?: SAUPAN006235000
- symbol?: isaA
- synonym:
- description?: immunodominant antigen A
- immunodominant antigen A
- transglycosylase IsaA
- immunodominant antigen A (IsaA)
- lytic transglycosylase IsaA
- immunodominant antigen A, transglycosylase isaA
- Immunodominant antigen A precursor
- immunodominant staphylococcal antigen A
- Immunodominant staphylococcal antigen A precursor
- putative transglycosylase isaA
- transglycosylase domain-containing protein
- transglycosylase-like domain protein
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 6300436..6301137
- synteny block?: BlockID0049590
- occurrence?: in 100% of 33 strains
isaA : peptidoglycan lytic transglycosylase IsaA [1]
- Staphylocci produce multiple cell wall remodeling enzymes that differ in where they digest peptidoglycan, their localization on the membrane and regulation of their activity
- Staphylococci produce one bifunctional N-acetylglucosaminidase/amidase: Atl (AtlA)
- Staphylococci produce three N-acetylglucosaminidases: SagA (LytD, AtlE), SagB and ScaH (Aly)
- Staphylococci produce two bifunctional amidase/endopeptidases: LytN and EssH
- Staphylococci produce two lytic transglycosylases: SceD and IsaA
- Staphylococci produce two monofunctional amidases: SsaA and Sle1
- Staphylococci produce three monofunctional endopeptidases: LytH, LytM and LytU
- Staphylococci produce five uncharacterized probable monofunctional amidases: (SsaA2), (SsaA3), (SsaA4), (SsaA5) and (SsaA6)
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2506 (isaA)
08BA02176:
C248_2627 (isaA)
11819-97:
MS7_2575 (isaA)
6850:
RSAU_002410 (isaA)
71193:
ST398NM01_2619
ECT-R 2:
ECTR2_2423
ED133:
SAOV_2614c
ED98:
SAAV_2635 (isaA)
HO 5096 0412:
SAEMRSA15_24720 (isaA)
JH1:
SaurJH1_2646
JH9:
SaurJH9_2591
JKD6008:
SAA6008_02607 (isaA)
JKD6159:
SAA6159_02464 (isaA)
LGA251:
SARLGA251_23440 (isaA)
M013:
M013TW_2543
MRSA252:
SAR2650 (isaA)
MSHR1132:
SAMSHR1132_23850
MSSA476:
SAS2455
Mu3:
SAHV_2553 (isaA)
Mu50:
SAV2569 (isaA)
MW2:
MW2490 (isaA)
RF122:
SAB2443c (isaA)
ST398:
SAPIG2619
T0131:
SAT0131_02779
TCH60:
HMPREF0772_10621 (isaA)
TW20:
SATW20_26900 (isaA)
USA300_TCH1516:
USA300HOU_2564 (isaA)
VC40:
SAVC_11725
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKKTIMASSLAVALGVTGYAAGTGHQAHAAEVNVDQAHLVDLAHNHQDQLNAAPIKDGAY
N315 MKKTIMASSLAVALGVTGYAAGTGHQAHAAEVNVDQAHLVDLAHNHQDQLNAAPIKDGAY
NCTC8325 MKKTIMASSLAVALGVTGYAAGTGHQAHAAEVNVDQAHLVDLAHNHQDQLNAAPIKDGAY
Newman MKKTIMASSLAVALGVTGYAAGTGHQAHAAEVNVDQAHLVDLAHNHQDQLNAAPIKDGAY
USA300_FPR3757 MKKTIMASSLAVALGVTGYAAGTGHQAHAAEVNVDQAHLVDLAHNHQDQLNAAPIKDGAY
************************************************************
COL DIHFVKDGFQYNFTSNGTTWSWSYEAANGQTAGFSNVAGADYTTSYNQGSNVQSVSYNAQ
N315 DIHFVKDGFQYNFTSNGTTWSWSYEAANGQTAGFSNVAGADYTTSYNQGSDVQSVSYNAQ
NCTC8325 DIHFVKDGFQYNFTSNGTTWSWSYEAANGQTAGFSNVAGADYTTSYNQGSNVQSVSYNAQ
Newman DIHFVKDGFQYNFTSNGTTWSWSYEAANGQTAGFSNVAGADYTTSYNQGSNVQSVSYNAQ
USA300_FPR3757 DIHFVKDGFQYNFTSNGTTWSWSYEAANGQTAGFSNVAGADYTTSYNQGSNVQSVSYNAQ
**************************************************:*********
COL SSNSNVEAVSAPTYHNYSTSTTSSSVRLSNGNTAGATGSSAAQIMAQRTGVSASTWAAII
N315 SSNSNVEAVSAPTYHNYSTSTTSSSVRLSNGNTAGATGSSAAQIMAQRTGVSASTWAAII
NCTC8325 SSNSNVEAVSAPTYHNYSTSTTSSSVRLSNGNTAGATGSSAAQIMAQRTGVSASTWAAII
Newman SSNSNVEAVSAPTYHNYSTSTTSSSVRLSNGNTAGATGSSAAQIMAQRTGVSASTWAAII
USA300_FPR3757 SSNSNVEAVSAPTYHNYSTSTTSSSVRLSNGNTAGATGSSAAQIMAQRTGVSASTWAAII
************************************************************
COL ARESNGQVNAYNPSGASGLFQTMPGWGPTNTVDQQINAAVKAYKAQGLGAWGF
N315 ARESNGQVNAYNPSGASGLFQTMPGWGPTNTVDQQINAAVKAYKAQGLGAWGF
NCTC8325 ARESNGQVNAYNPSGASGLFQTMPGWGPTNTVDQQINAAVKAYKAQGLGAWGF
Newman ARESNGQVNAYNPSGASGLFQTMPGWGPTNTVDQQINAAVKAYKAQGLGAWGF
USA300_FPR3757 ARESNGQVNAYNPSGASGLFQTMPGWGPTNTVDQQINAAVKAYKAQGLGAWGF
*****************************************************
- ↑ Min Wang, Girbe Buist, Jan Maarten van Dijl
Staphylococcus aureus cell wall maintenance - the multifaceted roles of peptidoglycan hydrolases in bacterial growth, fitness, and virulence.
FEMS Microbiol Rev: 2022, 46(5);
[PubMed:35675307] [WorldCat.org] [DOI] (I p)Min Wang, Xiaofang Li, Francis M Cavallo, Harita Yedavally, Sjouke Piersma, Elisa J M Raineri, Elias Vera Murguia, Jeroen Kuipers, Zhenhua Zhang, Jan Maarten van Dijl, Girbe Buist
Functional profiling of CHAP domain-containing peptidoglycan hydrolases of Staphylococcus aureus USA300 uncovers potential targets for anti-staphylococcal therapies.
Int J Med Microbiol: 2024, 316;151632
[PubMed:39142057] [WorldCat.org] [DOI] (I p)Melanie R Stapleton, Malcolm J Horsburgh, Emma J Hayhurst, Lynda Wright, Ing-Marie Jonsson, Andrej Tarkowski, John F Kokai-Kun, James J Mond, Simon J Foster
Characterization of IsaA and SceD, two putative lytic transglycosylases of Staphylococcus aureus.
J Bacteriol: 2007, 189(20);7316-25
[PubMed:17675373] [WorldCat.org] [DOI] (P p)