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NCBI: 10-JUN-2013
⊟Summary[edit | edit source]
- organism: Staphylococcus aureus USA300_FPR3757
- locus tag: SAUSA300_0412
- pan locus tag?: SAUPAN000587000
- symbol: SAUSA300_0412
- pan gene symbol?: —
- synonym:
- product:
⊟Additional information (user-provided)[edit | edit source]
ψtilA3 (ψlpl3): tandem TslA phospholipase immunity lipoprotein paralogue TilA3 pseudogene
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: pseudogene
- locus tag: SAUSA300_0412
- symbol: SAUSA300_0412
- product:
- replicon: chromosome
- strand: +
- coordinates: 465248..466055
- length: 808
- essential: unknown
⊟Accession numbers[edit | edit source]
- Gene ID: 3914677 NCBI
- RefSeq:
- BioCyc:
- MicrobesOnline: 1291927 MicrobesOnline
⊟Phenotype[edit | edit source]
⊟Additional information (user-provided)[edit | edit source]
⊟DNA sequence[edit | edit source]
- 1
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721
781ATGTGGTCAATAAAAAGAATTGGAATGTACACAAATGTTATAATTTTGAGCGTTTTTATA
ATAGGTTGTGATAGTTCAAGCAATAATGCAGAAAATCAAAGAGAAGACTCAAAAGAAGAA
CAAATCAAAAAGAGCTTTGCGAAAACGTTAGATATGTACCCTATTAAGAATCTCGAGGAT
TTATATGACAAAGAAGGATATCGTGATGGTGAGTTTGAAAAAGGCGATAAGGGGACGTGG
GTATTGTATTCAGCTATGGTATCACAACCAAAAGGCGAGAGTTTAAAATCACGAGGAATG
ATATTAAAGTTAGATAGAAATAAGAGAACTGCTAAAGGAAGTTATATTATTAGAGAATTG
AAAGAAGATAAAAATCATGATGTTCAAAAAAATGAAAAGAAATATCCAGTGAAATTGGTG
AATAATAGGATAGTTTTGATAAAAGATGTTAAAGACAAAAAGTTAAAAAAATGAAATAGA
GTCGTTTGAATTATTTTCACAATATGGAAACTTTAATCATTTTGATCGGAATGAGATTAC
TAATATTTCATATAATCCTAATGCTCCCAATTACTCTGCAGAATATAAAATGAAGAAAAA
TGACAGAAACATTCAACAGTTGAAAAAGAGATTTAATCTAAAAACTAGCAAGACACCAAA
ATTATTGTTTAAGGGATCTGGAGATATAAAGGGGTCTTCTGTAGGATATAAGGAAATAGA
AATCATATTTAGTAGAAGTAAAGAAGAAAGCATTTATTATGTTGACAGCGTTGAGTTCGT
TCCAAGTAACAAAATAACAAAAAGTTGA60
120
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808
⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SAUSA300_0412
- symbol: SAUSA300_0412
- description:
- length:
- theoretical pI:
- theoretical MW:
- GRAVY:
⊟Function[edit | edit source]
- TIGRFAM:
- TheSEED: data available for Newman
- PFAM:
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb:
- DeepLocPro:
- LocateP:
- SignalP:
- predicted transmembrane helices (TMHMM):
⊟Accession numbers[edit | edit source]
- GI:
- RefSeq:
- UniProt:
⊟Additional information (user-provided)[edit | edit source]
⊟Protein sequence[edit | edit source]
⊟Experimental data[edit | edit source]
- experimentally validated:
- protein localization:
- quantitative data / protein copy number per cell:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator: SaeR (activation) regulon
SaeR (TF) important in Virulence; RegPrecise transcription unit transferred from N315 data RegPrecise
⊟Additional information (user-provided)[edit | edit source]
⊟Transcription pattern[edit | edit source]
- S.aureus Expression Data Browser: no data available
⊟Protein synthesis (provided by Aureolib)[edit | edit source]
- Aureolib: no data available
⊟Protein stability[edit | edit source]
- half-life: no data available
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Additional information (user-provided)[edit | edit source]
⊟Other information (user-provided)[edit | edit source]
This locus is highly prone to recombination leading to gene duplication / loss. Gene nomenclature is confusing and appears to be numbered sequentially by position in the genome and is not intended to show homology between strains (e.g. the first instance of tilA/lpl in COL may have the greatest homology with the sixth instance in FPR3757 but the gene names would still be different [i.e. tilA1/lpl1 and tilA6/lpl6 in COL and FPR3757, respectively]).
⊟Literature[edit | edit source]
⊟References[edit | edit source]
⊟Relevant publications[edit | edit source]
- ↑ Stephen R Garrett, Nicole Mietrach, Justin Deme, Alina Bitzer, Yaping Yang, Fatima R Ulhuq, Dorothee Kretschmer, Simon Heilbronner, Terry K Smith, Susan M Lea, Tracy Palmer
A type VII-secreted lipase toxin with reverse domain arrangement.
Nat Commun: 2023, 14(1);8438
[PubMed:38114483] [WorldCat.org] [DOI] (I e)Stephen R Garrett, Giuseppina Mariano, Jo Dicks, Tracy Palmer
Homologous recombination between tandem paralogues drives evolution of a subset of type VII secretion system immunity genes in firmicute bacteria.
Microb Genom: 2022, 8(8);
[PubMed:35960642] [WorldCat.org] [DOI] (I p)