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Pangenome04-0298108BA0217611819-9771193COLECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50N315NCTC8325NewmanRF122ST398T0131TCH60TW20USA300_FPR3757USA300_TCH1516VC40
NCBI: 06-JUL-2013

Summary[edit source | edit]

  • organism: Staphylococcus aureus Newman
  • locus tag: NWMN_1715 [new locus tag: NWMN_RS09630 ]
  • pan locus tag?: SAUPAN004584000
  • symbol: bsaB
  • pan gene symbol?: epiB
  • synonym:
  • product: lantibiotic biosynthesis protein

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: NWMN_1715 [new locus tag: NWMN_RS09630 ]
  • symbol: bsaB
  • product: lantibiotic biosynthesis protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1911535..1914528
  • length: 2994
  • essential: unknown other strains

Accession numbers[edit source | edit]

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    2881
    2941
    ATGAACACTATTTACGAACCGTCAAGTATTTGTATGATTAGAACACCTTTATTATCAGTT
    GAATTTTTCAATTTATTTTTAAATACTGAACAAATTAAATATAGCGACTTACAATTAAAT
    GCTCAGATGAAAGAATCAATCCTAACAACAACATTTAACTTATATTGTACTTTACAAGAA
    ATAAATTTTGATGGCGATAACAAGAAGGTTAGAGATGCTAAAGAAAGTTTATTAAAATAT
    TTAATTAGAATGTCAACACGTCCAACTCCATTTGGATTATTAAGTGGTATTAATTTGGGG
    CATTTTGTAAATGAACCAACACGTCTTAAAGTTGGAAATAGTATTCAAAAATATGTGAAA
    GTCGATGGCGAATGGTTGTATAAACTGGTTAGTTATATTGAGAGTATTGATGAATATTAT
    CAAAATTTGAAAGTTATTTGGAATAGTAAAGCACATATTATCAATGATCGAATATATTTA
    AATGAACAAAGTGCTATTTATTTAAACAACAATAAAGATACATCTTTTTCCATTAAAAAT
    AGCGAATTACTCGTATTCATCAAAACCACTGTGACGAATAATAATATTACTTTTTCAAAT
    TTAGCTGAAAAGATAAATCAAGAATTTGAAATTAATGATATTACTAAAGTGAAAGTATAT
    ATCCATAATCTTGTCTCAAAGGAAATTATATATTCAACAATCAGACCACCGTTATCATAT
    AGCGATAATTTAAATTATATTTTAAATAAACTTTCTTTACATAATGATGATTTTGTGAAA
    AAAATTAGAGAAATCCAGAAATTGATATTAGCTTATGAAAAAACTGAAATTGGATTTGGC
    GAGGAATTATATAAAGACATTATTCATCATATGAAGGCACTATTCAAATGTAAAAACTAT
    CTTCAAATTGATACCAAAATTGACATGATTAACAATTATTTACATCAAGATATAGCAACA
    AATATATCTGAAGCAGCGTACTTATTGTGGCTTTTATCAAGAAATAATATTGGATTCACA
    GATTTGAAAGTTCTTCACAACCGTTTTATTGAAAAGTATGGATTTGAACAACTCGTGAAT
    ATTAAAGATTTGATTTCAGATATAACAGGTTTCGGGACAACAATTTTTCAAGAAGAAGAA
    ACCGATGGAAATAATATTGTAATGCTTAAGCAAAAATTTTTACATGCCTTGAGAAATAAC
    GATGAGATAGTCATAAATGAAAAAGATGTAGAGTCATTGATTAACGATAATGAAATCAAT
    CATTATCATGCGCCAATGAGTGCAGATGTTTATGCTGAACTTTATTTAGGACGTTTTTAC
    AATCAGTACAATGAGCTCATTGTTATTAGTCCTTTAACGGCGTCTTTTAATGCTGGCGCT
    ACATTTGGGCGATTTCATCATTTAATTGATACTGAAACTTTAGCAAAATTAGAACATGAA
    AAAGGACATTATTATCAGAAGATGATATGTGATGACAATGTAGAAATGATTTCTATAAAT
    AACATACCGAAATATCCGAGAAATCATAATGTATTAACTAATCATGACTCATACGAATAT
    TCATTGAATTTAGGAAGTAGTAATAGTTATTCAAAGTATGAGCTTACCTTAGATGATATT
    TATGTTGGTGCTACCTTTAACAAATTATATTTATATTCTAGCCAACTAAATAAAAGGGTA
    CTATTTGAATCAAACAATATGTATAACTTTTTAAAAGAATGTAATTTATATCGATTGTTA
    CGAGAAATTTCAATGGAATCTGTGAAATGCATTGAACCTATGAATGATGTGAGTATTGAT
    TCATTTAGTTATTCACCACGAATCAGATATAAAAATGTCATTCTTAAACCAGCATATTGG
    AAAATTAACGAGATGGTATTACCTTTACCTAAAAATGAAGAATGGGATCAACAATTTTTG
    AAATATCAAGAACAATTCAATATACCTAATATCGTGAATTTAGTTTATGGAGATAACAAG
    CTTCTACTAAATTTATCATTAGCTAATCATAGATATTTATTGATGAAAGAATATAAGAAG
    CATAAACGTGTACGTTTAGTAGAATCATTTTTACCTCAATCAAAGAATGATCATGTGTAT
    GAAATTGTTACACCAATTTATAAAAAATCATCTTATCGAGGACCCGAAATCGAAATTCCA
    AAATATAAAAATACAGATATTGAATATGACAAAGACTGGTTTGCATTACATATTCATATC
    GATAAGCCATCGCAAGATACATTTATCATCGACAATTTGTATCCATTTGTAAAACATCTT
    AAAGATAAGGGAGATATAGATCAATATTTTTTAATGCGTTATATCAAACAAGGTGACATT
    TTAAAGTTGAGGTTATTCAGGAATGACGAAAATTACGCAGAAATATACAGCATCTTGAAG
    AATTGGTTACCACATGTTCGACAAACGACAGAAGTTTCAGATTATGAATTTGTATCATAC
    GAGCCAGAATTTTTTAGATATGGTGGAAAGAACACGATTAATGAAATAGAAGCCTTCTTT
    GAATATGACACGAATTTAGCTGTCAATATTATTGAAAATGATTTTAAGTTTGATCGACCA
    TATATTGTTGCTATTTCAATAATGTATTTATTTGAGATGTTTTCAATTTCTAATGAAGAG
    CGTATGGAAATTGTTAATAACTATGTACCTACATCATTTAAAAGTAAAGATATTAGACCT
    TTTAAAAATGAACTTGTAACTATATGTAATCCTGCTAATAATTTTGAATATATGGCTAAA
    CACTATAGTGGTATTTATCGAATTTTAAAAGATGGCAACCAAATTTTGAGCAAATTAAAT
    GAAGGGCTTAAAAAAACTTTAACTACTAAAAGGTCAAGGATTATTGGCAGCTTAATTCAT
    ATGCGCTGCAATCGAATATTTGGCATTGATAAGGATCAAGAAACATTTGTTTTATCTATT
    GTAAAAGAAATTGTTAAAACTCAAAAGCATTGGTGTGGTGACAAAAATGATTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2640
    2700
    2760
    2820
    2880
    2940
    2994

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: NWMN_1715 [new locus tag: NWMN_RS09630 ]
  • symbol: BsaB
  • description: lantibiotic biosynthesis protein
  • length: 997
  • theoretical pI: 6.73397
  • theoretical MW: 117635
  • GRAVY: -0.405216

Function[edit source | edit]

  • reaction:
  • TIGRFAM:
    Cellular processesCellular processesToxin production and resistancethiopeptide-type bacteriocin biosynthesis domain (TIGR03891; HMM-score: 204.6)
  • TheSEED:  
    Lanthionine biosynthesis protein LanB 
  • PFAM:
    no clan definedLant_dehydr_N; Lantibiotic dehydratase, C terminus (PF04738; HMM-score: 503.8)
    Lant_dehydr_C; Lantibiotic biosynthesis dehydratase C-term (PF14028; HMM-score: 85)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 1.05
    • Cytoplasmic Membrane Score: 8.78
    • Cellwall Score: 0.08
    • Extracellular Score: 0.09
    • Internal Helices: 0
  • LocateP: Intracellular
    • Prediction by SwissProt Classification: Cytoplasmic
    • Pathway Prediction: No pathway
    • Intracellular Possibility: 1
    • Signal Peptide Possibility: -1
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • Ymax: 0.177
    • Ymax_pos: 11
    • Cmax: 0.132
    • Cmax_pos: 35
    • Smax: 0.479
    • Smax_pos: 2
    • Smean: 0.307
    • D: 0.228
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit source | edit]

Protein sequence[edit source | edit]

  • MNTIYEPSSICMIRTPLLSVEFFNLFLNTEQIKYSDLQLNAQMKESILTTTFNLYCTLQEINFDGDNKKVRDAKESLLKYLIRMSTRPTPFGLLSGINLGHFVNEPTRLKVGNSIQKYVKVDGEWLYKLVSYIESIDEYYQNLKVIWNSKAHIINDRIYLNEQSAIYLNNNKDTSFSIKNSELLVFIKTTVTNNNITFSNLAEKINQEFEINDITKVKVYIHNLVSKEIIYSTIRPPLSYSDNLNYILNKLSLHNDDFVKKIREIQKLILAYEKTEIGFGEELYKDIIHHMKALFKCKNYLQIDTKIDMINNYLHQDIATNISEAAYLLWLLSRNNIGFTDLKVLHNRFIEKYGFEQLVNIKDLISDITGFGTTIFQEEETDGNNIVMLKQKFLHALRNNDEIVINEKDVESLINDNEINHYHAPMSADVYAELYLGRFYNQYNELIVISPLTASFNAGATFGRFHHLIDTETLAKLEHEKGHYYQKMICDDNVEMISINNIPKYPRNHNVLTNHDSYEYSLNLGSSNSYSKYELTLDDIYVGATFNKLYLYSSQLNKRVLFESNNMYNFLKECNLYRLLREISMESVKCIEPMNDVSIDSFSYSPRIRYKNVILKPAYWKINEMVLPLPKNEEWDQQFLKYQEQFNIPNIVNLVYGDNKLLLNLSLANHRYLLMKEYKKHKRVRLVESFLPQSKNDHVYEIVTPIYKKSSYRGPEIEIPKYKNTDIEYDKDWFALHIHIDKPSQDTFIIDNLYPFVKHLKDKGDIDQYFLMRYIKQGDILKLRLFRNDENYAEIYSILKNWLPHVRQTTEVSDYEFVSYEPEFFRYGGKNTINEIEAFFEYDTNLAVNIIENDFKFDRPYIVAISIMYLFEMFSISNEERMEIVNNYVPTSFKSKDIRPFKNELVTICNPANNFEYMAKHYSGIYRILKDGNQILSKLNEGLKKTLTTKRSRIIGSLIHMRCNRIFGIDKDQETFVLSIVKEIVKTQKHWCGDKND

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]