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Pangenome04-0298108BA0217611819-9771193COLECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50N315NCTC8325NewmanRF122ST398T0131TCH60TW20USA300_FPR3757USA300_TCH1516VC40
NCBI: 06-JUL-2013

Summary[edit source | edit]

  • organism: Staphylococcus aureus Newman
  • locus tag: NWMN_1712 [new locus tag: NWMN_RS09615 ]
  • pan locus tag?: SAUPAN004575000
  • symbol: bsaP
  • pan gene symbol?: epiP
  • synonym:
  • product: lantibiotic leader peptide processing serine protease

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: NWMN_1712 [new locus tag: NWMN_RS09615 ]
  • symbol: bsaP
  • product: lantibiotic leader peptide processing serine protease
  • replicon: chromosome
  • strand: -
  • coordinates: 1908381..1909754
  • length: 1374
  • essential: unknown other strains

Accession numbers[edit source | edit]

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    ATGAAAATCATAAAGCGCGCTATTATTAGTTTAATAATATTGAGTCTTTTAATATCTATT
    ACAATGAGTAATGCATCAGCGTCAGAAGAACTATATTACAGTGTTGAATACAAAAATACA
    GCAACATTTAACAAGTTAGTTAAAAAGAAGTCCTTAAACGTTGTCTATAATATACCGGAA
    TTACATGTGGCACAGATTAAAATGACGAAAATGCATGCTAATGCTTTAGCAAACTATAAA
    AATGATATTAAATATATCAATGCCACATGTTCAACTTGTATTACTAGCGAGAAAACAATA
    GACAGAACATCAAATGAGTCATTATTTTCAAGACAATGGGATATGAATAAAATAACCAAT
    AATGGTGCATCGTATGATGATTTGCCAAAACATGCTAACACCAAAATAGCAATCATAGAT
    ACAGGTGTGATGAAAAACCATGACGATTTGAAAAATAATTTCTCGACTGATTCTAAAAAT
    TTAGTACCTTTAAACGGTTTTAGAGGTACTGAACCGGAGGAAACAGGTGATGTTCACGAT
    GTCAATGATAGGAAAGGACATGGCACGATGGTGTCGGGTCAAACGAGTGCTAATGGTAAG
    TTAATAGGTGTTGCACCGAATAACAAATTTACAATGTATCGCGTGTTTGGTAGTAAAAAA
    ACAGAACTGCTTTGGGTATCAAAAGCGATTGTTCAAGCTGCAAATGATGGAAATCAAGTC
    ATTAATATTAGTGTTGGTAGTTATATTATTTTGGACAAAAATGACCATCAAACATTTAGA
    AAAGATGAAAAAGTAGAATACGATGCGTTACAGAAAGCAATCAATTACGCCAAGAAGAAA
    AAATCTATCGTTGTTGCTGCAGCTGGTAATGATGGTATTGATGTCAATGACAAACAGAAA
    CTAAAATTACAGCGTGAATATCAAGGTAATGGCGAAGTGAAAGATGTTCCTGCATCTATG
    GACAATGTCGTTACAGTAGGATCTACAGATCAAAAGAGTAATCTATCTGAGTTTTCCAAT
    TTTGGTATGAATTATACAGATATTGCTGCGCCCGGAGGATCATTTGCTTATTTAAATCAA
    TTCGGTGTGGATAAATGGATGAATGAAGGGTATATGCATAAGGAGAACATTTTAACTACT
    GCCAATAACGGAAGATATATTTATCAAGCTGGAACTTCATTAGCCACACCTAAAGTTTCG
    GGAGCACTAGCTTTAATCATTGATAAATATCATCTTGAAAAACATCCAGATAAAGCGATT
    GAATTGTTATATCAGCATGGGACATCTAAGAATAATAAACCATTTAGTAGATATGGGCAT
    GGTGAGCTTGATGTGTATAAAGCATTAAATGTAGCAAATCAAAAAGCAAGTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1374

Protein[edit source | edit]

Protein Data Bank: 3QFH
Protein Data Bank: 3T41

General[edit source | edit]

  • locus tag: NWMN_1712 [new locus tag: NWMN_RS09615 ]
  • symbol: BsaP
  • description: lantibiotic leader peptide processing serine protease
  • length: 457
  • theoretical pI: 9.48761
  • theoretical MW: 50735.1
  • GRAVY: -0.497812

Function[edit source | edit]

  • reaction:
  • TIGRFAM:
    Genetic information processingProtein fateProtein and peptide secretion and traffickingtype VII secretion-associated serine protease mycosin (TIGR03921; EC 3.4.21.-; HMM-score: 136)
    Genetic information processingProtein fateProtein modification and repairtype VII secretion-associated serine protease mycosin (TIGR03921; EC 3.4.21.-; HMM-score: 136)
    cyanobactin maturation protease, PatA/PatG family (TIGR03895; EC 3.4.21.-; HMM-score: 50.3)
  • TheSEED:  
    Epidermin leader peptide processing serine protease epiP precursor (EC 3.4.21.-) 
  • PFAM:
    no clan definedPeptidase_S8; Subtilase family (PF00082; HMM-score: 146.4)
    DUF2850; Protein of unknown function (DUF2850) (PF11012; HMM-score: 13.1)
    DUF2960; Protein of unknown function (DUF2960) (PF11173; HMM-score: 12.5)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Extracellular
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0.09
    • Cellwall Score: 0.18
    • Extracellular Score: 9.73
    • Internal Helices: 0
  • LocateP: Secretory(released) (with CS)
    • Prediction by SwissProt Classification: Extracellular
    • Pathway Prediction: Sec-(SPI)
    • Intracellular Possibility: 0.17
    • Signal Peptide Possibility: 1
    • N-terminally Anchored Score: -1
    • Predicted Cleavage Site: SNASASEE
  • SignalP: Signal peptide length 28 aa
    • Ymax: 0.794
    • Ymax_pos: 28
    • Cmax: 0.811
    • Cmax_pos: 28
    • Smax: 0.899
    • Smax_pos: 13
    • Smean: 0.778
    • D: 0.787
  • predicted transmembrane helices (TMHMM): 1

Accession numbers[edit source | edit]

Protein sequence[edit source | edit]

  • MKIIKRAIISLIILSLLISITMSNASASEELYYSVEYKNTATFNKLVKKKSLNVVYNIPELHVAQIKMTKMHANALANYKNDIKYINATCSTCITSEKTIDRTSNESLFSRQWDMNKITNNGASYDDLPKHANTKIAIIDTGVMKNHDDLKNNFSTDSKNLVPLNGFRGTEPEETGDVHDVNDRKGHGTMVSGQTSANGKLIGVAPNNKFTMYRVFGSKKTELLWVSKAIVQAANDGNQVINISVGSYIILDKNDHQTFRKDEKVEYDALQKAINYAKKKKSIVVAAAGNDGIDVNDKQKLKLQREYQGNGEVKDVPASMDNVVTVGSTDQKSNLSEFSNFGMNYTDIAAPGGSFAYLNQFGVDKWMNEGYMHKENILTTANNGRYIYQAGTSLATPKVSGALALIIDKYHLEKHPDKAIELLYQHGTSKNNKPFSRYGHGELDVYKALNVANQKAS

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]