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NCBI: 06-JUL-2013

Summary[edit source | edit]

  • organism: Staphylococcus aureus Newman
  • locus tag: NWMN_2568 [new locus tag: NWMN_RS14735 ]
  • pan locus tag?: SAUPAN006414000
  • symbol: icaC
  • pan gene symbol?: icaC
  • synonym:
  • product: intercellular adhesion protein IcaC

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: NWMN_2568 [new locus tag: NWMN_RS14735 ]
  • symbol: icaC
  • product: intercellular adhesion protein IcaC
  • replicon: chromosome
  • strand: +
  • coordinates: 2835130..2836182
  • length: 1053
  • essential: unknown other strains

Accession numbers[edit source | edit]

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    ATGAAAAAGATTAGACTTGAACTCGTATATTTACGTGCTATTATATGTGCAATTATTATT
    ATCACACATTTACTTACACAAATTACTTTAAAACATGAAAATATGGAGGGTGGATCCTTA
    GTGTTACAATTTTACATTCGTAATATTGTGATTTTTGGTACACCTTGCTTTATTATCTTG
    TCACAGTTACTGACAACCTTGAATTACCAAAAAGTCACCTATAGATACTTAACTACACGC
    GTAAAATATATACTTATTCCTTACATATTAATGGGATTGTTTTACAGTTATAGTGAATCA
    TTATTAACAGATTCAAGTTTCAATAAACAATTCATTGAAAATGTCCTATTAGGTCAATGG
    TATGGCTATTTTATCGTTGTTATCATGCAATTCTTTATTTTGAGTTATATCATTTTTAAA
    ATTAACTATAACCTATTCAACAGTAAAATATTATTATTGTTATCTTTTATTTTACAGCAA
    TCATTTTTATATTACTTTACGAACAACACAGCGTTTCACGATACCGTGCTACACTATTAT
    CCATTAAGTGAAAATACTATAATATTCGGATGGATTTTTTATTTCTTCTTAGGTGCATAT
    ATGGGTTATAACTACGAACGTGTATTAAATTTCTTAGAACGTTATTTAGTTATTATGATT
    GTATTAGCTGTAGCTACTTATTTTGTGTTTATTGCGTTAGCAAATGGAGACTATTGGAAC
    GTTACCAGCTTTTCATATTCATTAACACCATATAATAGTATTATGTTTATTGTTATCTTG
    GGTATTTGCACGCATTTTAAAACAATGTTATTTAATACGATTCAAATGATTAGTGCTTTC
    TCATTCTTTATTTATTTATTACATCCAATCATTCTAGACTCATTGTTTGCATATACAAAT
    ATATTTGAGGATAATACAATGGTCTTTCTAGCGATATCACTACTATTCATTTTAGGATTA
    TGTATAGGTGTCGGCATGATATTGCGTGAATTCTATATCTTTAGGTTTATTATTGGAAAA
    CAACCATATAAATTGAACATTAATGCTTATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1053

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: NWMN_2568 [new locus tag: NWMN_RS14735 ]
  • symbol: IcaC
  • description: intercellular adhesion protein IcaC
  • length: 350
  • theoretical pI: 8.82602
  • theoretical MW: 41344
  • GRAVY: 0.806571

Function[edit source | edit]

  • reaction:
  • TIGRFAM:
  • TheSEED:  
    Regulation and Cell signalingQuorum sensing and biofilm formationBiofilm formation in Staphylococcus Polysaccharide intercellular adhesin (PIA) biosynthesis protein IcaC 
  • PFAM:
    Acyl_transf_3 (CL0316) Acyl_transf_3; Acyltransferase family (PF01757; HMM-score: 80)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 10
  • LocateP: Multi-transmembrane
    • Prediction by SwissProt Classification: Membrane
    • Pathway Prediction: Sec-(SPI)
    • Intracellular Possibility: 0.17
    • Signal Peptide Possibility: -1
    • N-terminally Anchored Score: -1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • Ymax: 0.17
    • Ymax_pos: 32
    • Cmax: 0.136
    • Cmax_pos: 32
    • Smax: 0.307
    • Smax_pos: 27
    • Smean: 0.193
    • D: 0.179
  • predicted transmembrane helices (TMHMM): 10

Accession numbers[edit source | edit]

Protein sequence[edit source | edit]

  • MKKIRLELVYLRAIICAIIIITHLLTQITLKHENMEGGSLVLQFYIRNIVIFGTPCFIILSQLLTTLNYQKVTYRYLTTRVKYILIPYILMGLFYSYSESLLTDSSFNKQFIENVLLGQWYGYFIVVIMQFFILSYIIFKINYNLFNSKILLLLSFILQQSFLYYFTNNTAFHDTVLHYYPLSENTIIFGWIFYFFLGAYMGYNYERVLNFLERYLVIMIVLAVATYFVFIALANGDYWNVTSFSYSLTPYNSIMFIVILGICTHFKTMLFNTIQMISAFSFFIYLLHPIILDSLFAYTNIFEDNTMVFLAISLLFILGLCIGVGMILREFYIFRFIIGKQPYKLNINAY

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

Regulation[edit source | edit]

  • sigma factor:
  • regulators: CodY, IcaR
    CodY (TF) important in Amino acid metabolism  RegPrecise    transcription unit transferred from N315 data RegPrecise
    IcaR (TF) important in Intercellular adhesion  RegPrecise    transcription unit transferred from N315 data RegPrecise

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]