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NCBI: 10-JUN-2013

Summary[edit source | edit]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL2675 [new locus tag: SACOL_RS14010 ]
  • pan locus tag?: SAUPAN006389000
  • symbol: secY
  • pan gene symbol?: secY2
  • synonym:
  • product: preprotein translocase subunit SecY

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: SACOL2675 [new locus tag: SACOL_RS14010 ]
  • symbol: secY
  • product: preprotein translocase subunit SecY
  • replicon: chromosome
  • strand: -
  • coordinates: 2746764..2747975
  • length: 1212
  • essential: unknown other strains

Accession numbers[edit source | edit]

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    ATGTTAAAACTTTTACAACAATACGAATATAAAATTATATATAAACGTATGCTATACACA
    TGTTTTATCTTGTTTATTTATATATTAGGCACAAACATTTCCATCGTTTCCTATAACGAT
    ATGCAAGTAAAACATGAGTCATTTTTTAAAATAGCTATTTCTAATATGGGTGGAGACGTT
    AATACTTTAAACATTTTCACTTTAGGATTAGGTCCGTGGTTAACATCAATGATTATCTTG
    ATGCTGATTTCTTATCGGAATATGGATAAATACATGAAACAAACAAGTCTTGAGAAGCAT
    TATAAAGAGCGCATCTTAACATTAATTTTAAGTGTTATTCAAAGTTATTTTGTGATTCAT
    GAATATGTTTCGAAAGAACGTGTTCATCAAGACAATATTTACTTAACAATATTGATTTTG
    GTTACTGGAACGATGTTATTAGTTTGGTTAGCTGACAAAAATAGTCGCTACGGCATCGCA
    GGACCAATGCCGATTGTAATGGTTAGTATTATTAAATCAATGATGCATCAAAAAATGGAA
    TATATAGATGCAAGTCATATTGTGATTGCGTTGTTAATCATCCTTGTGATAATCACATTG
    TTTATCTTATTATTTATTGAATTAGTAGAAGTGAGAATACCATATATCGATTTAATGAAC
    GTTTCCGCAACAAATATGAAATCTTATTTATCTTGGAAAGTTAACCCTGCAGGCAGTATT
    ACTTTAATGATGAGTATTTCAGCTTTTGTTTTCTTAAAAAGTGGCATTCATTTTATTTTA
    TCTATGTTTAATAAAAGCATATCAGATGACATGCCAATGCTGACATTTGATAGTCCAGTA
    GGTATTTCAGTATATTTAGTGATTCAAATGTTATTGGGTTATTTTTTATCGAGATTTTTA
    ATCAATACTAAACAAAAATCCAAAGATTTCTTAAAGAGTGGCAATTATTTTTCAGGAGTT
    AAACCTGGTAAGGATACAGAACGTTATTTAAATTATCAAGCACGACGCGTATGTTGGTTT
    GGATTGGCATTAGTTACAGTCATTATTGGTATACCGCTTTATTTCACATTGTTTGTACCG
    CATTTATCTACTGAAATTTATTTCTCAGTACAACTGATTGTATTAGTTTACATCAGTATT
    AATATTGCAGAAACAATTCGTACATATTTATATTTTGATAAATATAAGCCATTTTTAAAC
    CAGTATTGGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1212

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: SACOL2675 [new locus tag: SACOL_RS14010 ]
  • symbol: SecY
  • description: preprotein translocase subunit SecY
  • length: 403
  • theoretical pI: 9.60127
  • theoretical MW: 46884.8
  • GRAVY: 0.527543

Function[edit source | edit]

  • reaction:
  • TIGRFAM:
    Genetic information processingProtein fateProtein and peptide secretion and traffickingaccessory Sec system translocase SecY2 (TIGR02920; HMM-score: 563.6)
    Genetic information processingProtein fateProtein and peptide secretion and traffickingpreprotein translocase, SecY subunit (TIGR00967; HMM-score: 121.5)
  • TheSEED:  
    Membrane TransportProtein translocation across cytoplasmic membraneSecY2-SecA2 Specialized Transport System Preprotein translocase SecY2 subunit (TC 3.A.5.1.1) 
  • PFAM:
    no clan definedSecY; SecY translocase (PF00344; HMM-score: 148.3)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 8
  • LocateP: Multi-transmembrane
    • Prediction by SwissProt Classification: Membrane
    • Pathway Prediction: Sec-(SPI)
    • Intracellular Possibility: 0.17
    • Signal Peptide Possibility: -1
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • Ymax: 0.136
    • Ymax_pos: 39
    • Cmax: 0.146
    • Cmax_pos: 39
    • Smax: 0.206
    • Smax_pos: 7
    • Smean: 0.115
    • D: 0.128
  • predicted transmembrane helices (TMHMM): 10

Accession numbers[edit source | edit]

Protein sequence[edit source | edit]

  • MLKLLQQYEYKIIYKRMLYTCFILFIYILGTNISIVSYNDMQVKHESFFKIAISNMGGDVNTLNIFTLGLGPWLTSMIILMLISYRNMDKYMKQTSLEKHYKERILTLILSVIQSYFVIHEYVSKERVHQDNIYLTILILVTGTMLLVWLADKNSRYGIAGPMPIVMVSIIKSMMHQKMEYIDASHIVIALLIILVIITLFILLFIELVEVRIPYIDLMNVSATNMKSYLSWKVNPAGSITLMMSISAFVFLKSGIHFILSMFNKSISDDMPMLTFDSPVGISVYLVIQMLLGYFLSRFLINTKQKSKDFLKSGNYFSGVKPGKDTERYLNYQARRVCWFGLALVTVIIGIPLYFTLFVPHLSTEIYFSVQLIVLVYISINIAETIRTYLYFDKYKPFLNQYW

Experimental data[edit source | edit]

  • experimental localization: Integral membrane [1]

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

  1. Andreas Otto, Jan Maarten van Dijl, Michael Hecker, Dörte Becher
    The Staphylococcus aureus proteome.
    Int. J. Med. Microbiol.: 2014, 304(2);110-20
    [PubMed:24439828] [WorldCat.org] [DOI] (I p)

Relevant publications[edit source | edit]