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Pangenome04-0298108BA0217611819-9771193COLECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50N315NCTC8325NewmanRF122ST398T0131TCH60TW20USA300_FPR3757USA300_TCH1516VC40
NCBI: 26-AUG-2013

Summary[edit source | edit]

  • organism: Staphylococcus aureus N315
  • locus tag: SA1843 [new locus tag: SA_RS10580 ]
  • pan locus tag?: SAUPAN005277000
  • symbol: agrC
  • pan gene symbol?: agrC
  • synonym:
  • product: accessory gene regulator C

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: SA1843 [new locus tag: SA_RS10580 ]
  • symbol: agrC
  • product: accessory gene regulator C
  • replicon: chromosome
  • strand: +
  • coordinates: 2080353..2081468
  • length: 1116
  • essential: no DEG

Accession numbers[edit source | edit]

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    TTGATTCCAACTTTTTCATCTATCATATTTTTATTCTTTAAATTAAAGTACTATGCAATA
    GTAACAATTTTAGTGACCATGATCATAATGTATTTGAGTAATTTTGCAACAGTAGGTTTG
    TTTTTAACTTTAAGAAAATACACTACTGATCCTGCAATACTCTTACCATTATATATACTT
    TCTTTTTCATCAGTTTCATTATTAGCGACATATTTGGTAAGAATATCTCTAAAGAAATTT
    AAAAAATCATACTTATCTTTAAATAAAACTTATATGATTATAATTTCATTCGTATTATTT
    GCAACATTTGCATTTTTTTATATTTATTCTACAAATACAAGTTCAAACGGTGATAGCTTA
    ATTCCATATGCACTTGTATTTATAGGATTAATAATTTTTATCTCTGTTGTAATACTTATA
    ATGTCGCTTTTCACCCTTAAAGAGATGAAATACAAACGAAATCAAGAAGAAATTGAGACC
    TATTACGAATACACATTAAAGATTGAAGCAATTAATAATGAAATGCGCAAGTTCCGTCAT
    GATTATGTCAATATCTTAACGACACTTTCAGAATACATTCGCGAAGATGACATGATTGGT
    CTACGCGCTTATTTCAATAAAAATATTGTACCTATGAAAGATAATTTGCAGATGAATGCT
    ATTAAATTAAATGGTATCGAGAATCTTAAAGTACGTGAGATAAAAGGCTTAATTACTGCG
    AAAATTTTACGTGCACAAGAAATGAATATTCCAATTAGTATCGAAATACCCGATGAAGTA
    AGTAGCATTAACTTGAATATGATCGATTTAAGTCGCAGTATTGGTATTATTCTTGATAAT
    GCAATTGAGGCATCAACTGAAATTGATGACCCTATCATTCGCGTTGCATTTATTGAAAGT
    GAAAATTCAGTAACGTTTATTGTTATGAATAAATGCGCTGATGATATACCACGCATTCAT
    GAATTGTTCCAAGAAAGTTTTTCTACTAAAGGTGAAGGTCGTGGTTTAGGTCTATCAACT
    TTAAAAGAAATTGCTGATAATGCAGACAATGTCTTATTAGATACAATTATCGAAAATGGT
    TTCTTTATTCAAAAAGTTGAAATTATTAACAACTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1116

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: SA1843 [new locus tag: SA_RS10580 ]
  • symbol: AgrC
  • description: accessory gene regulator C
  • length: 371
  • theoretical pI: 5.28675
  • theoretical MW: 42544.7
  • GRAVY: 0.357143

Function[edit source | edit]

  • reaction:
  • TIGRFAM:
  • TheSEED:  
    Histidine kinase of the competence regulon ComD 
  • PFAM:
    His_Kinase_A (CL0025) HATPase_c_5; GHKL domain (PF14501; HMM-score: 66.6)
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518; HMM-score: 18.2)
    ABC-2 (CL0181) ABC2_membrane_2; ABC-2 family transporter protein (PF12679; HMM-score: 15.3)
    GHD (CL0369) Glyco_hydro_30C; Glycosyl hydrolase family 30 beta sandwich domain (PF17189; HMM-score: 14.7)
    no clan definedSPOB_a; Sensor_kinase_SpoOB-type, alpha-helical domain (PF14689; HMM-score: 13.8)
    NfeD-like (CL0252) NfeD; NfeD-like C-terminal, partner-binding (PF01957; HMM-score: 9.8)
    no clan definedDUF1772; Domain of unknown function (DUF1772) (PF08592; HMM-score: 8.5)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 4
  • LocateP: Multi-transmembrane
    • Prediction by SwissProt Classification: Membrane
    • Pathway Prediction: Sec-(SPI)
    • Intracellular Possibility: 0.17
    • Signal Peptide Possibility: -1
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • Ymax: 0.113
    • Ymax_pos: 12
    • Cmax: 0.125
    • Cmax_pos: 69
    • Smax: 0.185
    • Smax_pos: 6
    • Smean: 0.126
    • D: 0.118
  • predicted transmembrane helices (TMHMM): 4

Accession numbers[edit source | edit]

  • GI: 15927613 NCBI
  • RefSeq: NP_375146 NCBI
  • UniProt:

Protein sequence[edit source | edit]

  • MIPTFSSIIFLFFKLKYYAIVTILVTMIIMYLSNFATVGLFLTLRKYTTDPAILLPLYILSFSSVSLLATYLVRISLKKFKKSYLSLNKTYMIIISFVLFATFAFFYIYSTNTSSNGDSLIPYALVFIGLIIFISVVILIMSLFTLKEMKYKRNQEEIETYYEYTLKIEAINNEMRKFRHDYVNILTTLSEYIREDDMIGLRAYFNKNIVPMKDNLQMNAIKLNGIENLKVREIKGLITAKILRAQEMNIPISIEIPDEVSSINLNMIDLSRSIGIILDNAIEASTEIDDPIIRVAFIESENSVTFIVMNKCADDIPRIHELFQESFSTKGEGRGLGLSTLKEIADNADNVLLDTIIENGFFIQKVEIINN

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

Regulation[edit source | edit]

  • sigma factor:
  • regulators: AgrA, CodY
    AgrA (TF) important in Quorum sensing, Virulence  RegPrecise
    CodY (TF) important in Amino acid metabolism  RegPrecise

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]

Elizabeth A George Cisar, Edward Geisinger, Tom W Muir, Richard P Novick
Symmetric signalling within asymmetric dimers of the Staphylococcus aureus receptor histidine kinase AgrC.
Mol. Microbiol.: 2009, 74(1);44-57
[PubMed:19708918] [WorldCat.org] [DOI] (I p)