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NCBI: 10-JUN-2013

⊟Summary[edit | edit source]

organism: Staphylococcus aureus USA300_FPR3757
locus tag: SAUSA300_1448 [new locus tag: SAUSA300_RS07905 ]
pan locus tag^?: SAUPAN004031000
symbol: SAUSA300_1448
pan gene symbol^?: fur
synonym:
product: FUR family transcriptional regulator

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

type: CDS
locus tag: SAUSA300_1448 [new locus tag: SAUSA300_RS07905 ]
symbol: SAUSA300_1448
product: FUR family transcriptional regulator
replicon: chromosome
strand: -
coordinates: 1601372..1601821
length: 450
essential: unknown other strains

⊟Accession numbers[edit | edit source]

Gene ID: 3914025 NCBI
RefSeq: YP_494144 NCBI
BioCyc: see SAUSA300_RS07905
MicrobesOnline: 1292963 MicrobesOnline

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

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TTGGAAGAACGATTAAATCGCGTTAAGCAACAATTACAACAATCATCATATAAGCTAACG
CCACAACGCGAAGCTACTGTTAGAGTTCTAATTGAAAATGAAAAAGATCATCTAAGTGCT
GAAGACGTATATCTGAAAGTAAAAGATAAAGCGCCTGAAATTGGCTTGGCGACAGTATAC
AGAACGTTAGAGTTGTTAGCTGAACTAAAAGTTGTCGACAAAATTAACTTTGGTGATGGC
GTCGCTCGTTTTGATTTAAGAAAAGAAGGCGCAAAACATTTCCACCATCATTTAGTATGT
ATGGAATGTGGTCGTGTAGATGAAATCGATGAAGATTTGTTACCAGAAGTTGAAAATCGA
GTTGAAAATGAGTTCAATTTTAAAATTTTAGATCATCGTTTAACTTTCCATGGTGTGTGT
GAAACGTGCCAAGCTAAAGGTAAAGGATAG
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450

⊟Protein[edit | edit source]

⊟General[edit | edit source]

locus tag: SAUSA300_1448 [new locus tag: SAUSA300_RS07905 ]
symbol: SAUSA300_1448
description: FUR family transcriptional regulator
length: 149
theoretical pI: 6.15861
theoretical MW: 17243.6
GRAVY: -0.575168

⊟Function[edit | edit source]

TIGRFAM:
TheSEED :
- Ferric uptake regulation protein FUR
Stress Response Oxidative stress Oxidative stress Ferric uptake regulation protein FUR
PFAM:
HTH (CL0123) FUR; Ferric uptake regulator family (PF01475; HMM-score: 131.8)

⊟Structure, modifications & cofactors[edit | edit source]

domains:
modifications:
cofactors:
effector: Iron ion (Fe2+)
genes regulated by Fur*, TF important in Iron homeostasisRegPrecise
repression
sirC < sirB < sirA
sbnA* > sbnB* > sbnC > sbnD* > sbnE* > sbnF* > sbnG* > sbnH* > sbnI*
fepA* > fepB* > fepC*
tatC < tatA*
fhuA > fhuB > fhuG
sstA* > sstB* > sstC* > sstD*
ntrA*
isdB*
isdA*
isdC* > isdD* > isdE* > isdF* > srtB > isdG*
acnA
ftnA*
fhuD1*
htsC* < htsB* < htsA*
sfnaC* < sfnaB* < sfnaA*
sfnaD*
fhuD2*
iruO*
feoB < feoA
transcription units transferred from N315 data RegPrecise

⊟Localization[edit | edit source]

PSORTb: Cytoplasmic
- Cytoplasmic Score: 9.97
- Cytoplasmic Membrane Score: 0
- Cellwall Score: 0.01
- Extracellular Score: 0.02
- Internal Helices: 0
LocateP: Intracellular
- Prediction by SwissProt Classification: Cytoplasmic
- Pathway Prediction: No pathway
- Intracellular possibility: 1
- Signal peptide possibility: -1
- N-terminally Anchored Score: 1
- Predicted Cleavage Site: No CleavageSite
SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.001453
- TAT(Tat/SPI): 0.000154
- LIPO(Sec/SPII): 0.000214
predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

GI: 87160545 NCBI
RefSeq: YP_494144 NCBI
UniProt: A0A0H2XGT2 UniProt

⊟Protein sequence[edit | edit source]

MEERLNRVKQQLQQSSYKLTPQREATVRVLIENEKDHLSAEDVYLKVKDKAPEIGLATVYRTLELLAELKVVDKINFGDGVARFDLRKEGAKHFHHHLVCMECGRVDEIDEDLLPEVENRVENEFNFKILDHRLTFHGVCETCQAKGKG

⊟Experimental data[edit | edit source]

experimentally validated: data available for COL, NCTC8325
protein localization: data available for COL
quantitative data / protein copy number per cell: data available for COL
interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

MicrobesOnline: xerD < SAUSA300_1448

⊟Regulation[edit | edit source]

data available for N315

⊟Transcription pattern[edit | edit source]

S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

Aureolib: data available for COL

⊟Protein stability[edit | edit source]

half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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