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NCBI: 06-JUL-2013
⊟Summary[edit | edit source]
- organism: Staphylococcus aureus Newman
- locus tag: NWMN_1629 [new locus tag: NWMN_RS09145 ]
- pan locus tag?: SAUPAN004400000
- symbol: ccpA
- pan gene symbol?: ccpA
- synonym:
- product: catabolite control protein A
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: NWMN_1629 [new locus tag: NWMN_RS09145 ]
- symbol: ccpA
- product: catabolite control protein A
- replicon: chromosome
- strand: -
- coordinates: 1813146..1814135
- length: 990
- essential: unknown other strains
⊟Accession numbers[edit | edit source]
- Gene ID: 5331715 NCBI
- RefSeq: YP_001332663 NCBI
- BioCyc:
- MicrobesOnline: 3707181 MicrobesOnline
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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961ATGACAGTTACTATATATGATGTAGCAAGAGAAGCGCGTGTCTCTATGGCCACAGTGTCG
CGTGTTGTTAATGGGAACCAAAATGTTAAAGCAGAAACTAAAAATAAAGTTAACGAAGTC
ATTAAGCGTTTGAATTATCGTCCAAATGCTGTTGCTAGAGGTTTAGCTAGTAAAAAGACA
ACAACAGTAGGTGTGATCATTCCAGATATATCTAATATCTATTATTCACAACTTGCTCGT
GGACTTGAAGATATTGCAACAATGTATAAATATCACTCAATTATTTCAAATTCAGATAAC
GATCCTGAAAAGGAAAAAGAAATTTTTAATAACTTATTAAGTAAACAGGTTGATGGTATT
ATTTTCCTTGGTGGTACAATTACTGAAGAAATGAAAGAATTGATAAATCAATCATCTGTA
CCTGTAGTAGTATCAGGAACAAATGGTAAGGATGCACATATAGCATCAGTTAATATTGAT
TTTACTGAAGCTGCGAAAGAAATTACGGGAGAATTAATTGAAAAAGGCGCTAAATCATTT
GCTTTAGTAGGTGGAGAACATTCTAAAAAAGCTCAAGAAGATGTTTTAGAAGGTTTAACT
GAAGTGTTAAATAAAAATGGCCTTCAATTAGGTGATACATTGAATTGTTCTGGTGCTGAA
AGTTATAAAGAAGGCGTAAAAGCTTTTGCCAAAATGAAAGGCAATTTGCCAGATGCCATT
TTATGTATCAGCGACGAAGAAGCAATTGGTATTATGCATAGTGCAATGGATGCTGGTATT
AAAGTTCCAGAGGAATTACAAATTATTAGTTTCAATAATACACGATTAGTTGAGATGGTT
AGACCACAACTTTCTAGTGTTATTCAACCATTATATGATATCGGTGCAGTAGGGATGCGC
TTATTAACAAAATATATGAACGATGAAAAGATAGAAGAACCAAATGTAGTTTTACCTCAC
AGAATTGAATACCGAGGAACTACAAAATAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: NWMN_1629 [new locus tag: NWMN_RS09145 ]
- symbol: CcpA
- description: catabolite control protein A
- length: 329
- theoretical pI: 5.50763
- theoretical MW: 36060
- GRAVY: -0.229787
⊟Function[edit | edit source]
- TIGRFAM: Regulatory functions DNA interactions catabolite control protein A (TIGR01481; HMM-score: 570.3)and 5 moreRegulatory functions DNA interactions D-fructose-responsive transcription factor (TIGR02417; HMM-score: 159)Regulatory functions DNA interactions trehalose operon repressor (TIGR02405; HMM-score: 107.1)Mobile and extrachromosomal element functions Other addiction module antidote protein, HigA family (TIGR02607; HMM-score: 18.6)Regulatory functions DNA interactions addiction module antidote protein, HigA family (TIGR02607; HMM-score: 18.6)Regulatory functions Protein interactions addiction module antidote protein, HigA family (TIGR02607; HMM-score: 18.6)
- TheSEED: data available for COL, N315, NCTC8325, USA300_FPR3757
- PFAM: Periplas_BP (CL0144) Peripla_BP_3; Periplasmic binding protein-like domain (PF13377; HMM-score: 105.4)and 9 morePeripla_BP_4; Periplasmic binding protein domain (PF13407; HMM-score: 74.7)Peripla_BP_1; Periplasmic binding proteins and sugar binding domain of LacI family (PF00532; HMM-score: 71.1)HTH (CL0123) LacI; Bacterial regulatory proteins, lacI family (PF00356; HMM-score: 67.1)no clan defined ATP-synt_F; ATP synthase (F/14-kDa) subunit (PF01990; HMM-score: 16.2)4Fe-4S (CL0344) Fer4_12; 4Fe-4S single cluster domain (PF13353; HMM-score: 14.6)MurF-HprK_N (CL0365) Hpr_kinase_N; HPr Serine kinase N terminus (PF02603; HMM-score: 14.5)no clan defined DUF327; Protein of unknown function (DUF327) (PF03885; HMM-score: 13.9)HTH (CL0123) HTH_3; Helix-turn-helix (PF01381; HMM-score: 12.9)HTH_31; Helix-turn-helix domain (PF13560; HMM-score: 12.7)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors: binding of HPr-Ser46-P (phosphocarrier protein); Fructose-1,6-bisphosphate
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 9.97
- Cytoplasmic Membrane Score: 0
- Cellwall Score: 0.01
- Extracellular Score: 0.02
- Internal Helices: 0
- LocateP: Intracellular
- Prediction by SwissProt Classification: Cytoplasmic
- Pathway Prediction: No pathway
- Intracellular possibility: 1
- Signal peptide possibility: -1
- N-terminally Anchored Score: 1
- Predicted Cleavage Site: No CleavageSite
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.027924
- TAT(Tat/SPI): 0.004638
- LIPO(Sec/SPII): 0.00505
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MTVTIYDVAREARVSMATVSRVVNGNQNVKAETKNKVNEVIKRLNYRPNAVARGLASKKTTTVGVIIPDISNIYYSQLARGLEDIATMYKYHSIISNSDNDPEKEKEIFNNLLSKQVDGIIFLGGTITEEMKELINQSSVPVVVSGTNGKDAHIASVNIDFTEAAKEITGELIEKGAKSFALVGGEHSKKAQEDVLEGLTEVLNKNGLQLGDTLNCSGAESYKEGVKAFAKMKGNLPDAILCISDEEAIGIMHSAMDAGIKVPEELQIISFNNTRLVEMVRPQLSSVIQPLYDIGAVGMRLLTKYMNDEKIEEPNVVLPHRIEYRGTTK
⊟Experimental data[edit | edit source]
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
- MicrobesOnline: no polycistronic organisation predicted
⊟Regulation[edit | edit source]
- regulator: CcpA regulon
CcpA (TF) important in Carbon catabolism; RegPrecise
⊟Transcription pattern[edit | edit source]
- S.aureus Expression Data Browser: data available for NCTC8325
⊟Protein synthesis (provided by Aureolib)[edit | edit source]
⊟Protein stability[edit | edit source]
- half-life: no data available
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
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