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NCBI: 02-MAR-2017

Summary[edit source | edit]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL_RS07670 [old locus tag: SACOL1506 ]
  • pan locus tag?: SAUPAN003926000
  • symbol: SACOL_RS07670
  • pan gene symbol?: aroC
  • synonym:
  • product: chorismate synthase

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: SACOL_RS07670 [old locus tag: SACOL1506 ]
  • symbol: SACOL_RS07670
  • product: chorismate synthase
  • replicon: chromosome
  • strand: -
  • coordinates: 1547075..1548241
  • length: 1167
  • essential: unknown

Accession numbers[edit source | edit]

  • Location: NC_002951 (1547075..1548241) NCBI
  • MicrobesOnline:

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
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    361
    421
    481
    541
    601
    661
    721
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    1021
    1081
    1141
    ATGAGATACCTAACATCAGGAGAATCACATGGACCTCAATTAACAGTTATTGTTGAAGGT
    GTACCTGCAAATATAGAAATTAAGGTTGAGGATATTAATAAAGAAATGTTTAAGCGTCAA
    GGCGGTTACGGACGTGGACGTCGTATGCAAATTGAGAAAGATACAGTAGAAATAGTATCA
    GGCGTTAGAAATGGTTATACATTAGGTAGTCCAATTACTATGGTTGTAACCAATGATGAC
    TTTACGCATTGGAGAAAAATTATGGGAGCAGCTCCAATAAGTGAAGAAGAACGTGAAAAT
    ATGAAACGTACTATTACAAAACCAAGACCTGGTCATGCAGATTTGGTTGGAGGTATGAAA
    TATAATCATCGTGATTTACGAAATGTGCTAGAGCGATCATCTGCTAGAGAAACAGCAGCT
    CGAGTTGCAGTCGGTGCCTTATGTAAAGTGTTATTACAACAGTTAGATATCGATATATAC
    AGTCGTGTTGTTGAAATAGGTGGAATTAAAGATAAAGATTTTTATGATTCAGAAACATTT
    AAAGCAAATCTTGATCGTAATGATGTTCGTGTAATTGATGACAGTATCGCACAAGCAATG
    CGAGATAAAATTGACGAAGCTAAAAATGAAGGAGATTCAATTGGCGGTGTCGTTCAAGTT
    GTAGTTGAAAATATGCCTGTTGGTGTAGGTAGTTATGTGCATTATGATCGTAAGTTAGAT
    GGTAAGATTGCACAAGGTGTTGTCAGCATAAATGCTTTTAAAGGTGTAAGCTTTGGTGAA
    GGATTTAAAGCAGCTGAAAAGCCAGGTAGTGAGATTCAAGATGAAATTCTATATAATAGT
    GAAATTGGTTATTATCGTGGATCTAATCACTTAGGTGGTTTAGAAGGCGGTATGTCAAAT
    GGAATGCCAATTATCGTTAATGGTGTAATGAAACCAATTCCAACGTTATATAAACCATTA
    AATTCAGTAGACATTAATACTAAAGAAGACTTTAAAGCAACAATTGAACGTTCTGATAGT
    TGTGCTGTTCCTGCAGCAAGTATCGTCTGCGAACATGTCGTAGCATTTGAAATAGCAAAA
    GCATTATTGGAAGAATTCCAATCAAATCATATTGAGCAACTTAAACAACAAATTATTGAG
    CGCAGACAATTAAATATTGAGTTTTAA
    60
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    1140
    1167

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: SACOL_RS07670 [old locus tag: SACOL1506 ]
  • symbol: SACOL_RS07670
  • description: chorismate synthase
  • length: 388
  • theoretical pI: 5.71849
  • theoretical MW: 43046.6
  • GRAVY: -0.363918

Function[edit source | edit]

  • reaction:
    EC 4.2.3.5?  ExPASy
    Chorismate synthase5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate
  • TIGRFAM:
    MetabolismAmino acid biosynthesisAromatic amino acid familychorismate synthase (TIGR00033; EC 4.2.3.5; HMM-score: 404.6)
    Unknown functionEnzymes of unknown specificityarchaeal radical SAM protein, PTO1314 family (TIGR03961; HMM-score: 12.6)
  • TheSEED:
  • PFAM:
    no clan definedChorismate_synt; Chorismate synthase (PF01264; HMM-score: 393.2)

Structure, modifications & interactions[edit source | edit]

Localization[edit source | edit]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • LocateP:
  • SignalP: no predicted signal peptide
    • Ymax: 0.125
    • Ymax_pos: 26
    • Cmax: 0.13
    • Cmax_pos: 26
    • Smax: 0.189
    • Smax_pos: 17
    • Smean: 0.107
    • D: 0.118
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit source | edit]

  • GI: 447192673 NCBI
  • RefSeq: WP_001269929 NCBI
  • UniProt:

Protein sequence[edit source | edit]

  • MRYLTSGESHGPQLTVIVEGVPANIEIKVEDINKEMFKRQGGYGRGRRMQIEKDTVEIVSGVRNGYTLGSPITMVVTNDDFTHWRKIMGAAPISEEERENMKRTITKPRPGHADLVGGMKYNHRDLRNVLERSSARETAARVAVGALCKVLLQQLDIDIYSRVVEIGGIKDKDFYDSETFKANLDRNDVRVIDDSIAQAMRDKIDEAKNEGDSIGGVVQVVVENMPVGVGSYVHYDRKLDGKIAQGVVSINAFKGVSFGEGFKAAEKPGSEIQDEILYNSEIGYYRGSNHLGGLEGGMSNGMPIIVNGVMKPIPTLYKPLNSVDINTKEDFKATIERSDSCAVPAASIVCEHVVAFEIAKALLEEFQSNHIEQLKQQIIERRQLNIEF

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

  • SACOL_RS07670 no polycistronic organisation predicted

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 1.18 1.19 1.20 1.21 1.22 1.23 1.24 1.25 1.26 1.27 1.28 1.29 1.30 1.31 1.32 1.33 1.34 1.35 1.36 1.37 1.38 1.39 1.40 1.41 1.42 1.43 1.44 1.45 1.46 1.47 1.48 1.49 1.50 1.51 1.52 1.53 1.54 1.55 1.56 1.57 1.58 1.59 1.60 1.61 1.62 1.63 1.64 1.65 1.66 1.67 1.68 1.69 1.70 1.71 1.72 1.73 1.74 1.75 1.76 1.77 1.78 1.79 1.80 1.81 1.82 1.83 1.84 1.85 1.86 1.87 1.88 1.89 1.90 1.91 1.92 1.93 1.94 Artem Cherkasov, Michael Hsing, Roya Zoraghi, Leonard J Foster, Raymond H See, Nikolay Stoynov, Jihong Jiang, Sukhbir Kaur, Tian Lian, Linda Jackson, Huansheng Gong, Rick Swayze, Emily Amandoron, Farhad Hormozdiari, Phuong Dao, Cenk Sahinalp, Osvaldo Santos-Filho, Peter Axerio-Cilies, Kendall Byler, William R McMaster, Robert C Brunham, B Brett Finlay, Neil E Reiner
    Mapping the protein interaction network in methicillin-resistant Staphylococcus aureus.
    J. Proteome Res.: 2011, 10(3);1139-50
    [PubMed:21166474] [WorldCat.org] [DOI] (I p)

Relevant publications[edit source | edit]